Entity Details

Primary name GHR_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP16882
EntryNameGHR_MOUSE
FullNameGrowth hormone receptor
TaxID10090
Evidenceevidence at protein level
Length650
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesGhr

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0004896 cytokine receptor activity
GO:0004903 growth hormone receptor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006897 endocytosis
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0009755 hormone-mediated signaling pathway
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0017046 peptide hormone binding
GO:0019221 cytokine-mediated signaling pathway
GO:0019530 taurine metabolic process
GO:0019838 growth factor binding
GO:0019898 extrinsic component of membrane
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019955 cytokine binding
GO:0032355 response to estradiol
GO:0032870 cellular response to hormone stimulus
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042169 SH2 domain binding
GO:0042445 hormone metabolic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042976 activation of Janus kinase activity
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0060396 growth hormone receptor signaling pathway
GO:0070195 growth hormone receptor complex
GO:1901215 negative regulation of neuron death

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003528 Long hematopoietin receptor, single chain, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015152 Growth hormone/erythropoietin receptor, ligand bindingDomainDomain
IPR025871 Growth hormone-binding proteinDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions