Entity Details

Primary name MK11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15759
EntryNameMK11_HUMAN
FullNameMitogen-activated protein kinase 11
TaxID9606
Evidenceevidence at protein level
Length364
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAPK11

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001649 osteoblast differentiation
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007265 Ras protein signal transduction
GO:0010628 positive regulation of gene expression
GO:0032735 positive regulation of interleukin-12 production
GO:0035556 intracellular signal transduction
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051149 positive regulation of muscle cell differentiation
GO:0051403 stress-activated MAPK cascade
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060348 bone development
GO:0071347 cellular response to interleukin-1
GO:0098586 cellular response to virus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003527 Mitogen-activated protein (MAP) kinase, conserved siteSiteConserved site
IPR008352 Mitogen-activated protein (MAP) kinase p38-likeFamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB01017 MinocyclineDrugbanksmall molecule
DB05157 KC706Drugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MK11_HUMANGYS1_MOUSEBioGRID14680475 details