Entity Details

Primary name NCOA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15788
EntryNameNCOA1_HUMAN
FullNameNuclear receptor coactivator 1
TaxID9606
Evidenceevidence at protein level
Length1441
SequenceStatuscomplete
DateCreated2004-10-11
DateModified2021-06-02

Ontological Relatives

GenesNCOA1

GO terms

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GOName
GO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0002155 regulation of thyroid hormone mediated signaling pathway
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007595 lactation
GO:0008584 male gonad development
GO:0015721 bile acid and bile salt transport
GO:0016922 nuclear receptor binding
GO:0017162 aryl hydrocarbon receptor binding
GO:0019216 regulation of lipid metabolic process
GO:0019899 enzyme binding
GO:0021549 cerebellum development
GO:0021766 hippocampus development
GO:0021854 hypothalamus development
GO:0021987 cerebral cortex development
GO:0030331 estrogen receptor binding
GO:0030374 nuclear receptor coactivator activity
GO:0030522 intracellular receptor signaling pathway
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0032991 protein-containing complex
GO:0033142 progesterone receptor binding
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043967 histone H4 acetylation
GO:0044849 estrous cycle
GO:0044877 protein-containing complex binding
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045925 positive regulation of female receptivity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046965 retinoid X receptor binding
GO:0046983 protein dimerization activity
GO:0047485 protein N-terminus binding
GO:0060179 male mating behavior
GO:0060713 labyrinthine layer morphogenesis
GO:1904017 cellular response to Thyroglobulin triiodothyronine
GO:2001038 regulation of cellular response to drug

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR009110 Nuclear receptor coactivator, interlockingFamilyHomologous superfamily
IPR010011 Nuclear receptor coactivator, DUF1518DomainDomain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013767 PAS foldDomainDomain
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlockingDomainDomain
IPR014935 Nuclear receptor coactivator, receptor-binding domainDomainDomain
IPR017426 Nuclear receptor coactivatorFamilyFamily
IPR028819 Nuclear receptor coactivator 1FamilyFamily
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR037077 Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01645 GenisteinDrugbanksmall molecule
DB04652 CorticosteroneDrugbanksmall molecule
DB06832 PrinaberelDrugbanksmall molecule
DB06875 ERB-196Drugbanksmall molecule
DB06908 (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACIDDrugbanksmall molecule
DB06927 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILEDrugbanksmall molecule
DB07009 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OLDrugbanksmall molecule
DB07080 TO-901317Drugbanksmall molecule
DB07119 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOLDrugbanksmall molecule
DB07150 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIMEDrugbanksmall molecule
DB07198 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILEDrugbanksmall molecule
DB07215 GW-590735Drugbanksmall molecule
DB07230 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONEDrugbanksmall molecule
DB07236 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OLDrugbanksmall molecule
DB07530 (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diolDrugbanksmall molecule
DB07557 3,20-PregnanedioneDrugbanksmall molecule
DB07724 IndeglitazarDrugbanksmall molecule
DB08220 (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acidDrugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB08742 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)Drugbanksmall molecule
DB08915 AleglitazarDrugbanksmall molecule