Entity Details

Primary name ITSN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15811
EntryNameITSN1_HUMAN
FullNameIntersectin-1
TaxID9606
Evidenceevidence at protein level
Length1721
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesITSN1

GO terms

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GOName
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006887 exocytosis
GO:0006897 endocytosis
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007420 brain development
GO:0015031 protein transport
GO:0016032 viral process
GO:0016197 endosomal transport
GO:0030027 lamellipodium
GO:0034613 cellular protein localization
GO:0035556 intracellular signal transduction
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043197 dendritic spine
GO:0048013 ephrin receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0055037 recycling endosome
GO:0060090 molecular adaptor activity
GO:0060124 positive regulation of growth hormone secretion
GO:0060999 positive regulation of dendritic spine development
GO:0061024 membrane organization
GO:0070064 proline-rich region binding
GO:0097440 apical dendrite
GO:0098793 presynapse
GO:0098871 postsynaptic actin cytoskeleton
GO:0098978 glutamatergic synapse
GO:0150007 clathrin-dependent synaptic vesicle endocytosis
GO:1905274 regulation of modification of postsynaptic actin cytoskeleton
GO:2001288 positive regulation of caveolin-mediated endocytosis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Cytoplasmic vesicle
Endomembrane system
Endosome
Membrane
Nucleus envelope
Recycling endosome

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000261 EH domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001452 SH3 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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