Entity Details

Primary name EZH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15910
EntryNameEZH2_HUMAN
FullNameHistone-lysine N-methyltransferase EZH2
TaxID9606
Evidenceevidence at protein level
Length746
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesEZH2

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005677 chromatin silencing complex
GO:0005737 cytoplasm
GO:0006306 DNA methylation
GO:0006325 chromatin organization
GO:0006348 chromatin silencing at telomere
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell population proliferation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0014013 regulation of gliogenesis
GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016571 histone methylation
GO:0018024 histone-lysine N-methyltransferase activity
GO:0019058 viral life cycle
GO:0021695 cerebellar cortex development
GO:0021766 hippocampus development
GO:0030183 B cell differentiation
GO:0031490 chromatin DNA binding
GO:0032355 response to estradiol
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0035098 ESC/E(Z) complex
GO:0035984 cellular response to trichostatin A
GO:0036333 hepatocyte homeostasis
GO:0042054 histone methyltransferase activity
GO:0042752 regulation of circadian rhythm
GO:0043021 ribonucleoprotein complex binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043547 positive regulation of GTPase activity
GO:0045120 pronucleus
GO:0045605 negative regulation of epidermal cell differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046976 histone methyltransferase activity (H3-K27 specific)
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0048468 cell development
GO:0048511 rhythmic process
GO:0051154 negative regulation of striated muscle cell differentiation
GO:0070301 cellular response to hydrogen peroxide
GO:0070314 G1 to G0 transition
GO:0070317 negative regulation of G0 to G1 transition
GO:0070734 histone H3-K27 methylation
GO:0070878 primary miRNA binding
GO:0071168 protein localization to chromatin
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0097421 liver regeneration
GO:0098532 histone H3-K27 trimethylation
GO:1900006 positive regulation of dendrite development
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:1904772 response to tetrachloromethane
GO:1990841 promoter-specific chromatin binding
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001005 SANT/Myb domainDomainDomain
IPR001214 SET domainDomainDomain
IPR021654 Histone-lysine N-methyltransferase EZH1/EZH2FamilyFamily
IPR026489 CXC domainDomainDomain
IPR033467 Tesmin/TSO1-like CXC domainDomainDomain
IPR041343 Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domainDomainDomain
IPR041355 Pre-SET CXC domainDomainDomain
IPR044439 EZH2, SET domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB12887 TazemetostatDrugbanksmall molecule
DB14581 CPI-1205Drugbanksmall molecule

Interactions

3 interactions