Entity Details

Primary name MK14_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16539
EntryNameMK14_HUMAN
FullNameMitogen-activated protein kinase 14
TaxID9606
Evidenceevidence at protein level
Length360
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAPK14

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000187 obsolete activation of MAPK activity
GO:0000902 cell morphogenesis
GO:0000922 spindle pole
GO:0001502 cartilage condensation
GO:0001525 angiogenesis
GO:0001649 osteoblast differentiation
GO:0001890 placenta development
GO:0002062 chondrocyte differentiation
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004708 MAP kinase kinase activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006006 glucose metabolic process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007519 skeletal muscle tissue development
GO:0010628 positive regulation of gene expression
GO:0010831 positive regulation of myotube differentiation
GO:0016607 nuclear speck
GO:0018105 peptidyl-serine phosphorylation
GO:0019395 fatty acid oxidation
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030168 platelet activation
GO:0030278 regulation of ossification
GO:0030316 osteoclast differentiation
GO:0031281 positive regulation of cyclase activity
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032495 response to muramyl dipeptide
GO:0032735 positive regulation of interleukin-12 production
GO:0034774 secretory granule lumen
GO:0035331 negative regulation of hippo signaling
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0035994 response to muscle stretch
GO:0038066 p38MAPK cascade
GO:0042307 positive regulation of protein import into nucleus
GO:0042770 signal transduction in response to DNA damage
GO:0043312 neutrophil degranulation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046326 positive regulation of glucose import
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048273 mitogen-activated protein kinase p38 binding
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051525 NFAT protein binding
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060348 bone development
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071356 cellular response to tumor necrosis factor
GO:0071479 cellular response to ionizing radiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090336 positive regulation of brown fat cell differentiation
GO:0090400 stress-induced premature senescence
GO:0098586 cellular response to virus
GO:0098978 glutamatergic synapse
GO:0099179 regulation of synaptic membrane adhesion
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1901741 positive regulation of myoblast fusion
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904813 ficolin-1-rich granule lumen
GO:2000379 positive regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003527 Mitogen-activated protein (MAP) kinase, conserved siteSiteConserved site
IPR008352 Mitogen-activated protein (MAP) kinase p38-likeFamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR038784 Mitogen-activated protein kinase 14FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01017 MinocyclineDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB01761 4-[5-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-1-methyl-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidineDrugbanksmall molecule
DB01807 N-[(3Z)-5-Tert-butyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-ylidene]-N'-(4-chlorophenyl)ureaDrugbanksmall molecule
DB01948 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-OneDrugbanksmall molecule
DB01953 Inhibitor of P38 KinaseDrugbanksmall molecule
DB01988 6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)PyrazineDrugbanksmall molecule
DB02195 3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]PyridineDrugbanksmall molecule
DB02277 1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-UreaDrugbanksmall molecule
DB02352 3-(Benzyloxy)Pyridin-2-AmineDrugbanksmall molecule
DB02873 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-OneDrugbanksmall molecule
DB02984 4-[3-Methylsulfanylanilino]-6,7-DimethoxyquinazolineDrugbanksmall molecule
DB03044 DoramapimodDrugbanksmall molecule
DB03110 2-ChlorophenolDrugbanksmall molecule
DB03980 4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4-Pyrimidinyl)ImidazoleDrugbanksmall molecule
DB04338 SB220025Drugbanksmall molecule
DB04632 4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDEDrugbanksmall molecule
DB04797 TriazolopyridineDrugbanksmall molecule
DB05157 KC706Drugbanksmall molecule
DB05412 TalmapimodDrugbanksmall molecule
DB05470 VX-702Drugbanksmall molecule
DB06518 R-1487Drugbanksmall molecule
DB06882 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylureaDrugbanksmall molecule
DB06940 N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamideDrugbanksmall molecule
DB06991 N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamideDrugbanksmall molecule
DB07138 NeflamapimodDrugbanksmall molecule
DB07307 N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamideDrugbanksmall molecule
DB07459 4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDEDrugbanksmall molecule
DB07607 4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINEDrugbanksmall molecule
DB07811 N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamideDrugbanksmall molecule
DB07829 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINEDrugbanksmall molecule
DB07832 4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehydeDrugbanksmall molecule
DB07833 N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamideDrugbanksmall molecule
DB07834 N-(cyclopropylmethyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamideDrugbanksmall molecule
DB07835 N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamideDrugbanksmall molecule
DB07941 PH-797804Drugbanksmall molecule
DB07942 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridineDrugbanksmall molecule
DB07943 SD-0006Drugbanksmall molecule
DB08064 N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREADrugbanksmall molecule
DB08068 N-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO-Drugbanksmall molecule
DB08091 3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDEDrugbanksmall molecule
DB08092 3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamideDrugbanksmall molecule
DB08093 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINEDrugbanksmall molecule
DB08095 3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREADrugbanksmall molecule
DB08096 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUMDrugbanksmall molecule
DB08097 2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINEDrugbanksmall molecule
DB08242 N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamideDrugbanksmall molecule
DB08349 N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamideDrugbanksmall molecule
DB08351 N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamideDrugbanksmall molecule
DB08352 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amineDrugbanksmall molecule
DB08395 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONEDrugbanksmall molecule
DB08423 [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONEDrugbanksmall molecule
DB08424 [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONEDrugbanksmall molecule
DB08521 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridineDrugbanksmall molecule
DB08522 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLEDrugbanksmall molecule
DB08730 3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

4 interactions