Entity Details

Primary name CDC37_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16543
EntryNameCDC37_HUMAN
FullNameHsp90 co-chaperone Cdc37
TaxID9606
Evidenceevidence at protein level
Length378
SequenceStatuscomplete
DateCreated2002-06-20
DateModified2021-06-02

Ontological Relatives

GenesCDC37

GO terms

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GOName
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006457 protein folding
GO:0006605 protein targeting
GO:0010608 posttranscriptional regulation of gene expression
GO:0019887 protein kinase regulator activity
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0031072 heat shock protein binding
GO:0038128 ERBB2 signaling pathway
GO:0050821 protein stabilization
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0051879 Hsp90 protein binding
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0060544 regulation of necroptotic process
GO:0070062 extracellular exosome
GO:0097110 scaffold protein binding
GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization
GO:0101031 chaperone complex
GO:1990565 HSP90-CDC37 chaperone complex

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR004918 Cdc37FamilyFamily
IPR013855 Cdc37, N-terminal domainDomainDomain
IPR013873 Cdc37, C-terminalDomainDomain
IPR013874 Cdc37, Hsp90 bindingDomainDomain
IPR038189 Cdc37, Hsp90-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CDC37_HUMANKSR1_MOUSEBioGRID, MINT10409742 26549023 details
CDC37_HUMANSTK11_MOUSEBioGRID12489981 details