Entity Details

Primary name SPI1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP17433
EntryNameSPI1_MOUSE
FullNameTranscription factor PU.1
TaxID10090
Evidenceevidence at protein level
Length272
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesSpi1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001944 vasculature development
GO:0002314 germinal center B cell differentiation
GO:0002316 follicular B cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0002327 immature B cell differentiation
GO:0002357 defense response to tumor cell
GO:0002572 pro-T cell differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008134 transcription factor binding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0030098 lymphocyte differentiation
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030225 macrophage differentiation
GO:0030851 granulocyte differentiation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034401 chromatin organization involved in regulation of transcription
GO:0035019 somatic stem cell population maintenance
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0042826 histone deacetylase binding
GO:0043011 myeloid dendritic cell differentiation
GO:0043314 negative regulation of neutrophil degranulation
GO:0043565 sequence-specific DNA binding
GO:0043966 histone H3 acetylation
GO:0044027 hypermethylation of CpG island
GO:0045347 negative regulation of MHC class II biosynthetic process
GO:0045646 regulation of erythrocyte differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051525 NFAT protein binding
GO:0060033 anatomical structure regression
GO:0070102 interleukin-6-mediated signaling pathway
GO:0071361 cellular response to ethanol
GO:0090241 negative regulation of histone H4 acetylation
GO:0090402 oncogene-induced cell senescence
GO:0098508 endothelial to hematopoietic transition
GO:0120186 negative regulation of protein localization to chromatin
GO:0140297 DNA-binding transcription factor binding
GO:0140311 protein sequestering activity
GO:1900745 positive regulation of p38MAPK cascade
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1901674 regulation of histone H3-K27 acetylation
GO:1902262 apoptotic process involved in blood vessel morphogenesis
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904151 positive regulation of microglial cell mediated cytotoxicity
GO:1904178 negative regulation of adipose tissue development
GO:1904238 pericyte cell differentiation
GO:1905036 positive regulation of antifungal innate immune response
GO:1905453 regulation of myeloid progenitor cell differentiation
GO:2000529 positive regulation of myeloid dendritic cell chemotaxis

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000418 Ets domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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