Entity Details - PICKLE: A Protein InteraCtion KnowLedgebasE

Accession	P18293
EntryName	ANPRA_MOUSE
FullName	Atrial natriuretic peptide receptor 1
TaxID	10090
Evidence	evidence at protein level
Length	1057
SequenceStatus	complete
DateCreated	1990-11-01
DateModified	2021-06-02

Genes

Npr1

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GO	Name
GO:0001653	peptide receptor activity
GO:0004383	guanylate cyclase activity
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0005886	plasma membrane
GO:0006182	cGMP biosynthetic process
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0010753	positive regulation of cGMP-mediated signaling
GO:0016021	integral component of membrane
GO:0016941	natriuretic peptide receptor activity
GO:0017046	peptide hormone binding
GO:0019934	cGMP-mediated signaling
GO:0035556	intracellular signal transduction
GO:0042417	dopamine metabolic process
GO:0042562	hormone binding
GO:0043235	receptor complex
GO:0048662	negative regulation of smooth muscle cell proliferation

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Subcellular Location
Membrane

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Domain	Name	Category	Type
IPR000719	Protein kinase domain	Domain	Domain
IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	Domain	Domain
IPR001170	Adenylyl cyclase class-4/guanylyl cyclase	Family	Family
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain	Domain
IPR001828	Receptor, ligand binding region	Domain	Domain
IPR011009	Protein kinase-like domain superfamily	Family	Homologous superfamily
IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site	Site	Conserved site
IPR028082	Periplasmic binding protein-like I	Family	Homologous superfamily
IPR029787	Nucleotide cyclase	Family	Homologous superfamily

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2 interactions

Interactor	Partner	Sources	Publications	Link
ANPRA_MOUSE	SEM3A_MOUSE	BioGRID	10520994	details
ANPRA_MOUSE	PLXA1_MOUSE	BioGRID	10520994	details