Entity Details

Primary name FAS_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP19096
EntryNameFAS_MOUSE
FullNameFatty acid synthase
TaxID10090
Evidenceevidence at protein level
Length2504
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesFasn

GO terms

Show/Hide Table
GOName
GO:0002068 glandular epithelial cell development
GO:0004312 fatty acid synthase activity
GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity
GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0004317 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006084 acetyl-CoA metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008611 ether lipid biosynthetic process
GO:0008659 (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
GO:0008693 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
GO:0009888 tissue development
GO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity
GO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity
GO:0030223 neutrophil differentiation
GO:0030224 monocyte differentiation
GO:0030879 mammary gland development
GO:0031177 phosphopantetheine binding
GO:0042470 melanosome
GO:0042587 glycogen granule
GO:0042802 identical protein binding
GO:0047117 enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
GO:0047451 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO:0071353 cellular response to interleukin-4
GO:0090557 establishment of endothelial intestinal barrier
GO:0102131 3-oxo-glutaryl-[acp] methyl ester reductase activity
GO:0102132 3-oxo-pimeloyl-[acp] methyl ester reductase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Melanosome

Domains

Show/Hide Table
DomainNameCategoryType
IPR001031 ThioesteraseDomainDomain
IPR001227 Acyl transferase domain superfamilyFamilyHomologous superfamily
IPR006162 Phosphopantetheine attachment sitePTMPTM
IPR009081 Phosphopantetheine binding ACP domainDomainDomain
IPR011032 GroES-like superfamilyFamilyHomologous superfamily
IPR013149 Alcohol dehydrogenase, C-terminalDomainDomain
IPR013217 Methyltransferase type 12DomainDomain
IPR013968 Polyketide synthase, ketoreductase domainDomainDomain
IPR014030 Beta-ketoacyl synthase, N-terminalDomainDomain
IPR014031 Beta-ketoacyl synthase, C-terminalDomainDomain
IPR014043 Acyl transferaseDomainDomain
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipaseFamilyHomologous superfamily
IPR016036 Malonyl-CoA ACP transacylase, ACP-bindingFamilyHomologous superfamily
IPR016039 Thiolase-likeFamilyHomologous superfamily
IPR018201 Beta-ketoacyl synthase, active siteSiteActive site
IPR020806 Polyketide synthase, phosphopantetheine-binding domainDomainDomain
IPR020807 Polyketide synthase, dehydratase domainDomainDomain
IPR020841 Polyketide synthase, beta-ketoacyl synthase domainDomainDomain
IPR020843 Polyketide synthase, enoylreductase domainDomainDomain
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR032821 Polyketide synthase, C-terminal extensionDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily
IPR036736 ACP-like superfamilyFamilyHomologous superfamily
IPR042104 Polyketide synthase, dehydratase domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table