Entity Details

Primary name THRB_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP19221
EntryNameTHRB_MOUSE
FullNameProthrombin
TaxID10090
Evidenceevidence at protein level
Length618
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesF2

GO terms

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GOName
GO:0001530 lipopolysaccharide binding
GO:0001934 positive regulation of protein phosphorylation
GO:0004252 serine-type endopeptidase activity
GO:0005102 signaling receptor binding
GO:0005509 calcium ion binding
GO:0005615 extracellular space
GO:0006953 acute-phase response
GO:0007166 cell surface receptor signaling pathway
GO:0007596 blood coagulation
GO:0008047 enzyme activator activity
GO:0008201 heparin binding
GO:0008233 peptidase activity
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009611 response to wounding
GO:0009897 external side of plasma membrane
GO:0010468 regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030168 platelet activation
GO:0030194 positive regulation of blood coagulation
GO:0030307 positive regulation of cell growth
GO:0032967 positive regulation of collagen biosynthetic process
GO:0042730 fibrinolysis
GO:0045861 negative regulation of proteolysis
GO:0048712 negative regulation of astrocyte differentiation
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051838 cytolysis by host of symbiont cells
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0062023 collagen-containing extracellular matrix
GO:0070053 thrombospondin receptor activity
GO:0070493 thrombin-activated receptor signaling pathway
GO:0070945 neutrophil-mediated killing of gram-negative bacterium
GO:0090218 positive regulation of lipid kinase activity
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1900182 positive regulation of protein localization to nucleus
GO:1900738 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
GO:2000379 positive regulation of reactive oxygen species metabolic process

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000001 KringleDomainDomain
IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR003966 Prothrombin/thrombinFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018056 Kringle, conserved siteSiteConserved site
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR018992 Thrombin light chainDomainDomain
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyFamilyHomologous superfamily
IPR037111 Thrombin light chain domain superfamilyFamilyHomologous superfamily
IPR038178 Kringle superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
THRB_MOUSEPAR3_MOUSEDIP17606903 details
THRB_MOUSEPAR4_MOUSEDIP17606903 details