Entity Details

Primary name ESR1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP19785
EntryNameESR1_MOUSE
FullNameEstrogen receptor
TaxID10090
Evidenceevidence at protein level
Length599
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesEsr1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001093 TFIIB-class transcription factor binding
GO:0001223 transcription coactivator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001547 antral ovarian follicle growth
GO:0002064 epithelial cell development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003707 steroid hormone receptor activity
GO:0004879 nuclear receptor activity
GO:0005496 steroid binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008209 androgen metabolic process
GO:0008270 zinc ion binding
GO:0008584 male gonad development
GO:0010629 negative regulation of gene expression
GO:0010863 positive regulation of phospholipase C activity
GO:0017025 TBP-class protein binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030284 estrogen receptor activity
GO:0030315 T-tubule
GO:0030331 estrogen receptor binding
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0031798 type 1 metabotropic glutamate receptor binding
GO:0032355 response to estradiol
GO:0032991 protein-containing complex
GO:0034056 estrogen response element binding
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0035327 transcriptionally active chromatin
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
GO:0042562 hormone binding
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043195 terminal bouton
GO:0043204 perikaryon
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043523 regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0043627 response to estrogen
GO:0044877 protein-containing complex binding
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045839 negative regulation of mitotic nuclear division
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046325 negative regulation of glucose import
GO:0048146 positive regulation of fibroblast proliferation
GO:0048471 perinuclear region of cytoplasm
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048863 stem cell differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050727 regulation of inflammatory response
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051117 ATPase binding
GO:0060011 Sertoli cell proliferation
GO:0060065 uterus development
GO:0060068 vagina development
GO:0060523 prostate epithelial cord elongation
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060745 mammary gland branching involved in pregnancy
GO:0060749 mammary gland alveolus development
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071168 protein localization to chromatin
GO:0071391 cellular response to estrogen stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0090209 negative regulation of triglyceride metabolic process
GO:0097550 transcription preinitiation complex
GO:1901215 negative regulation of neuron death
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Golgi apparatus
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001292 Estrogen receptorFamilyFamily
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR024178 Estrogen receptor/oestrogen-related receptorFamilyFamily
IPR024736 Oestrogen-type nuclear receptor final C-terminal domainDomainDomain
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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