Entity Details

Primary name GNAS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5JWF2
EntryNameGNAS1_HUMAN
FullNameGuanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
TaxID9606
Evidenceevidence at protein level
Length1037
SequenceStatuscomplete
DateCreated2006-10-17
DateModified2021-06-02

Ontological Relatives

GenesGNAS

GO terms

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GOName
GO:0001664 G protein-coupled receptor binding
GO:0001894 tissue homeostasis
GO:0001958 endochondral ossification
GO:0003924 GTPase activity
GO:0005159 insulin-like growth factor receptor binding
GO:0005525 GTP binding
GO:0005829 cytosol
GO:0005834 heterotrimeric G-protein complex
GO:0006112 energy reserve metabolic process
GO:0006306 DNA methylation
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007606 sensory perception of chemical stimulus
GO:0010856 adenylate cyclase activator activity
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030425 dendrite
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0031698 beta-2 adrenergic receptor binding
GO:0031748 D1 dopamine receptor binding
GO:0031852 mu-type opioid receptor binding
GO:0035116 embryonic hindlimb morphogenesis
GO:0035255 ionotropic glutamate receptor binding
GO:0035264 multicellular organism growth
GO:0040032 post-embryonic body morphogenesis
GO:0042493 response to drug
GO:0043588 skin development
GO:0045669 positive regulation of osteoblast differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0046872 metal ion binding
GO:0048589 developmental growth
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0051216 cartilage development
GO:0051430 corticotropin-releasing hormone receptor 1 binding
GO:0060348 bone development
GO:0070062 extracellular exosome
GO:0070527 platelet aggregation
GO:0071514 genetic imprinting
GO:0120162 positive regulation of cold-induced thermogenesis
GO:2000828 regulation of parathyroid hormone secretion

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane

Domains

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DomainNameCategoryType
IPR000367 G-protein alpha subunit, group SFamilyFamily
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunitFamilyFamily
IPR011025 G protein alpha subunit, helical insertionFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
GNAS1_HUMANRIC8B_MOUSEBioGRID20133939 details
GNAS1_HUMANOPRM_MOUSEMINT22177524 details