Entity Details

Primary name LRRK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5S007
EntryNameLRRK2_HUMAN
FullNameLeucine-rich repeat serine/threonine-protein kinase 2
TaxID9606
Evidenceevidence at protein level
Length2527
SequenceStatuscomplete
DateCreated2006-01-24
DateModified2021-06-02

Ontological Relatives

GenesLRRK2

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000149 SNARE binding
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0000287 magnesium ion binding
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0003779 actin binding
GO:0003924 GTPase activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005096 GTPase activator activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005764 lysosome
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005798 Golgi-associated vesicle
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0006468 protein phosphorylation
GO:0006606 protein import into nucleus
GO:0006897 endocytosis
GO:0006914 autophagy
GO:0006979 response to oxidative stress
GO:0007005 mitochondrion organization
GO:0007029 endoplasmic reticulum organization
GO:0007030 Golgi organization
GO:0007040 lysosome organization
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0007528 neuromuscular junction development
GO:0008017 microtubule binding
GO:0008340 determination of adult lifespan
GO:0009267 cellular response to starvation
GO:0010506 regulation of autophagy
GO:0010508 positive regulation of autophagy
GO:0010738 regulation of protein kinase A signaling
GO:0010955 negative regulation of protein processing
GO:0010977 negative regulation of neuron projection development
GO:0014041 regulation of neuron maturation
GO:0015631 tubulin binding
GO:0016234 inclusion body
GO:0016242 negative regulation of macroautophagy
GO:0016301 kinase activity
GO:0016310 phosphorylation
GO:0017075 syntaxin-1 binding
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019722 calcium-mediated signaling
GO:0021756 striatum development
GO:0021772 olfactory bulb development
GO:0022028 tangential migration from the subventricular zone to the olfactory bulb
GO:0030159 signaling receptor complex adaptor activity
GO:0030276 clathrin binding
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030672 synaptic vesicle membrane
GO:0031267 small GTPase binding
GO:0031398 positive regulation of protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031647 regulation of protein stability
GO:0031966 mitochondrial membrane
GO:0032091 negative regulation of protein binding
GO:0032092 positive regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032473 cytoplasmic side of mitochondrial outer membrane
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032839 dendrite cytoplasm
GO:0034211 GTP-dependent protein kinase activity
GO:0034260 negative regulation of GTPase activity
GO:0034599 cellular response to oxidative stress
GO:0034613 cellular protein localization
GO:0035556 intracellular signal transduction
GO:0035564 regulation of kidney size
GO:0035640 exploration behavior
GO:0035641 locomotory exploration behavior
GO:0035751 regulation of lysosomal lumen pH
GO:0036479 peroxidase inhibitor activity
GO:0039706 co-receptor binding
GO:0040012 regulation of locomotion
GO:0042391 regulation of membrane potential
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043068 positive regulation of programmed cell death
GO:0043195 terminal bouton
GO:0043204 perikaryon
GO:0043231 intracellular membrane-bounded organelle
GO:0043406 positive regulation of MAP kinase activity
GO:0044325 transmembrane transporter binding
GO:0044753 amphisome
GO:0044754 autolysosome
GO:0045121 membrane raft
GO:0046039 GTP metabolic process
GO:0046777 protein autophosphorylation
GO:0048312 intracellular distribution of mitochondria
GO:0048812 neuron projection morphogenesis
GO:0051018 protein kinase A binding
GO:0051646 mitochondrion localization
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051900 regulation of mitochondrial depolarization
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060070 canonical Wnt signaling pathway
GO:0060079 excitatory postsynaptic potential
GO:0060159 regulation of dopamine receptor signaling pathway
GO:0060161 positive regulation of dopamine receptor signaling pathway
GO:0060628 regulation of ER to Golgi vesicle-mediated transport
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0061001 regulation of dendritic spine morphogenesis
GO:0070062 extracellular exosome
GO:0070585 protein localization to mitochondrion
GO:0070971 endoplasmic reticulum exit site
GO:0070973 protein localization to endoplasmic reticulum exit site
GO:0070997 neuron death
GO:0071287 cellular response to manganese ion
GO:0071407 cellular response to organic cyclic compound
GO:0072593 reactive oxygen species metabolic process
GO:0090140 regulation of mitochondrial fission
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090394 negative regulation of excitatory postsynaptic potential
GO:0097487 multivesicular body, internal vesicle
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099400 caveola neck
GO:0099523 presynaptic cytosol
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0140058 neuron projection arborization
GO:1900244 positive regulation of synaptic vesicle endocytosis
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901727 positive regulation of histone deacetylase activity
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902499 positive regulation of protein autoubiquitination
GO:1902692 regulation of neuroblast proliferation
GO:1902803 regulation of synaptic vesicle transport
GO:1902823 negative regulation of late endosome to lysosome transport
GO:1902902 negative regulation of autophagosome assembly
GO:1903125 negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
GO:1903206 negative regulation of hydrogen peroxide-induced cell death
GO:1903215 negative regulation of protein targeting to mitochondrion
GO:1903217 negative regulation of protein processing involved in protein targeting to mitochondrion
GO:1903351 cellular response to dopamine
GO:1903980 positive regulation of microglial cell activation
GO:1904713 beta-catenin destruction complex binding
GO:1904887 Wnt signalosome assembly
GO:1905279 regulation of retrograde transport, endosome to Golgi
GO:1905289 regulation of CAMKK-AMPK signaling cascade
GO:1990904 ribonucleoprotein complex
GO:1990909 Wnt signalosome
GO:2000172 regulation of branching morphogenesis of a nerve
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasmic vesicle
Endoplasmic reticulum membrane
Endosome
Golgi apparatus membrane
Lysosome
Mitochondrion outer membrane
Perikaryon

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR005225 Small GTP-binding protein domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020859 Roc domainDomainDomain
IPR025875 Leucine rich repeat 4RepeatRepeat
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032171 C-terminal of Roc (COR) domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule