Entity Details

Primary name PO5F1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP20263
EntryNamePO5F1_MOUSE
FullNamePOU domain, class 5, transcription factor 1
TaxID10090
Evidenceevidence at protein level
Length352
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesPou5f1

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001710 mesodermal cell fate commitment
GO:0001711 endodermal cell fate commitment
GO:0001712 ectodermal cell fate commitment
GO:0001714 endodermal cell fate specification
GO:0001824 blastocyst development
GO:0001829 trophectodermal cell differentiation
GO:0001832 blastocyst growth
GO:0003130 BMP signaling pathway involved in heart induction
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0008134 transcription factor binding
GO:0009786 regulation of asymmetric cell division
GO:0010033 response to organic substance
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0017053 transcription repressor complex
GO:0019827 stem cell population maintenance
GO:0019955 cytokine binding
GO:0030718 germ-line stem cell population maintenance
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0032526 response to retinoic acid
GO:0035019 somatic stem cell population maintenance
GO:0035198 miRNA binding
GO:0043565 sequence-specific DNA binding
GO:0045165 cell fate commitment
GO:0045596 negative regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0048863 stem cell differentiation
GO:0051898 negative regulation of protein kinase B signaling
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060795 cell fate commitment involved in formation of primary germ layer
GO:0060913 cardiac cell fate determination
GO:0060965 negative regulation of gene silencing by miRNA
GO:0070974 POU domain binding
GO:0071837 HMG box domain binding
GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090308 regulation of DNA methylation-dependent heterochromatin assembly
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1990830 cellular response to leukemia inhibitory factor
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000327 POU-specific domainDomainDomain
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR010982 Lambda repressor-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013847 POU domainDomainDomain
IPR015585 POU domain-containing protein, class 5FamilyFamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

Show/Hide Table

Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
PO5F1_MOUSEKPYM_MOUSEIntAct18191611 details
PO5F1_MOUSEEWS_MOUSEBioGRID, IntAct15917470 17093407 details
PO5F1_MOUSENANOG_MOUSEBioGRID, DIP, IntAct17093407 18436640 18454139 20362541 22036565 23395962 23444350 details
PO5F1_MOUSEH4_MOUSEBioGRID, IntAct20362542 23452852 23798425 details
PO5F1_MOUSESOX2_MOUSEBioGRID, IntAct, MINT15863505 17507372 20362541 21962512 22036565 22344693 23108051 31077711 details
PO5F1_MOUSECDK1_MOUSEBioGRID, MINT17093407 23108051 details
PO5F1_MOUSECTCF_HUMANDIP19536159 details
PO5F1_MOUSEUBC9_MOUSEBioGRID17097055 details
PO5F1_MOUSESOX15_MOUSEBioGRID15863505 22344693 details
PO5F1_MOUSEWWP2_MOUSEBioGRID15047715 details
PO5F1_MOUSECDX2_MOUSEBioGRID16325584 details
PO5F1_MOUSESOX17_MOUSEBioGRID22344693 details
PO5F1_MOUSESOX5_MOUSEBioGRID22344693 details
PO5F1_MOUSESOX18_MOUSEBioGRID22344693 details
PO5F1_MOUSESOX14_MOUSEBioGRID22344693 details
PO5F1_MOUSESOX21_MOUSEBioGRID22344693 details
PO5F1_MOUSENR0B1_MOUSEBioGRID, IntAct17093407 20362541 details
PO5F1_MOUSEMBD3_MOUSEBioGRID, IntAct18454139 20362541 20362542 22083510 details
PO5F1_MOUSESP16H_MOUSEBioGRID, IntAct20362542 22083510 details
PO5F1_MOUSESALL4_MOUSEBioGRID, DIP, IntAct19060217 20362541 20362542 22083510 23269686 details
PO5F1_MOUSESSRP1_MOUSEBioGRID, IntAct20362542 22083510 details
PO5F1_MOUSEPO5F1_MOUSEBioGRID, IntAct18454139 20362542 22036565 22083510 31077711 details
PO5F1_MOUSEPARP1_MOUSEIntAct20362542 details
PO5F1_MOUSEOGT1_MOUSEBioGRID, IntAct20362541 20362542 22083510 22608532 details
PO5F1_MOUSEMTA2_MOUSEBioGRID, IntAct18454139 20362541 20362542 22083510 details
PO5F1_MOUSEMSH6_MOUSEBioGRID, IntAct20362542 22083510 details
PO5F1_MOUSEARI3B_MOUSEBioGRID, IntAct17093407 20362541 20362542 22083510 details
PO5F1_MOUSEWDR5_MOUSEBioGRID, IntAct20362541 21477851 22083510 23452852 details
PO5F1_MOUSEASH2L_MOUSEBioGRID, IntAct21477851 22083510 details
PO5F1_MOUSESMAD3_MOUSEIntAct22036565 details
PO5F1_MOUSERYBP_MOUSEBioGRID, IntAct17093407 20362541 28111200 details
PO5F1_MOUSEHDAC2_MOUSEBioGRID, IntAct17093407 18454139 20362541 details
PO5F1_MOUSEERR2_MOUSEBioGRID, IntAct18662995 20362541 22083510 details
PO5F1_MOUSEZN143_MOUSEBioGRID, IntAct18687992 20362541 details
PO5F1_MOUSERBBP7_MOUSEBioGRID, IntAct18454139 20362541 22083510 details
PO5F1_MOUSERING2_MOUSEBioGRID, IntAct20362541 22083510 details
PO5F1_MOUSEZMYM2_MOUSEBioGRID, IntAct20362541 22083510 details
PO5F1_MOUSENUCL_MOUSEBioGRID, IntAct21048921 details
PO5F1_MOUSECTCF_MOUSEDIP19536159 details
PO5F1_MOUSETYY1_MOUSEDIP19536159 details
PO5F1_MOUSETIF1B_MOUSEDIP20508149 details
PO5F1_MOUSEMSH2_MOUSEBioGRID20362541 22083510 details
PO5F1_MOUSECTNB1_MOUSEBioGRID22083510 23444350 details
PO5F1_MOUSEKIF11_MOUSEBioGRID22083510 details
PO5F1_MOUSEPP1G_MOUSEBioGRID22083510 details
PO5F1_MOUSERAD21_MOUSEBioGRID21589869 22083510 details
PO5F1_MOUSECDC20_MOUSEBioGRID22084091 details
PO5F1_MOUSELMBL2_MOUSEBioGRID22770845 details
PO5F1_MOUSECADH1_MOUSEBioGRID23444350 details