Entity Details

Primary name MDR3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP21440
EntryNameMDR3_MOUSE
FullNamePhosphatidylcholine translocator ABCB4
TaxID10090
Evidenceevidence at protein level
Length1276
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesAbcb4

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030136 clathrin-coated vesicle
GO:0032376 positive regulation of cholesterol transport
GO:0032782 bile acid secretion
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
GO:0045121 membrane raft
GO:0045332 phospholipid translocation
GO:0046581 intercellular canaliculus
GO:0055088 lipid homeostasis
GO:0061092 positive regulation of phospholipid translocation
GO:0090554 phosphatidylcholine floppase activity
GO:0090555 phosphatidylethanolamine flippase activity
GO:0099038 ceramide floppase activity
GO:1901557 response to fenofibrate
GO:1903413 cellular response to bile acid
GO:2001140 positive regulation of phospholipid transport

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Membrane raft

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR011527 ABC transporter type 1, transmembrane domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030275 Multidrug resistance protein 3FamilyFamily
IPR036640 ABC transporter type 1, transmembrane domain superfamilyFamilyHomologous superfamily
IPR039421 Type 1 protein exporterFamilyFamily

Diseases

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Interactions

0 interactions

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