Entity Details

Primary name MDR1A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP21447
EntryNameMDR1A_MOUSE
FullNameATP-dependent translocase ABCB1
TaxID10090
Evidenceevidence at protein level
Length1276
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesAbcb1a

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0016324 apical plasma membrane
GO:0022857 transmembrane transporter activity
GO:0043215 daunorubicin transport
GO:0046581 intercellular canaliculus
GO:0070633 transepithelial transport
GO:0140328 floppase activity
GO:1901529 positive regulation of anion channel activity
GO:1902396 protein localization to bicellular tight junction
GO:1905039 carboxylic acid transmembrane transport
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane
GO:2001225 regulation of chloride transport
GO:0005654 nucleoplasm
GO:0008559 ABC-type xenobiotic transporter activity
GO:0009914 hormone transport
GO:0009986 cell surface
GO:0016020 membrane
GO:0016887 ATP hydrolysis activity
GO:0031625 ubiquitin protein ligase binding
GO:0045177 apical part of cell
GO:0045332 phospholipid translocation
GO:0047484 regulation of response to osmotic stress
GO:0055085 transmembrane transport
GO:0060548 negative regulation of cell death
GO:1990962 xenobiotic transport across blood-brain barrier
GO:2001025 positive regulation of response to drug
GO:0033231 carbohydrate export
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
GO:0046865 terpenoid transport
GO:0099038 ceramide floppase activity
GO:0140115 export across plasma membrane
GO:1904478 regulation of intestinal absorption
GO:1990963 establishment of blood-retinal barrier
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0015562 efflux transmembrane transporter activity
GO:0016021 integral component of membrane
GO:0031526 brush border membrane
GO:0035633 maintenance of blood-brain barrier
GO:0046943 carboxylic acid transmembrane transporter activity
GO:0050892 intestinal absorption
GO:0060856 establishment of blood-brain barrier
GO:0072089 stem cell proliferation
GO:0090554 phosphatidylcholine floppase activity
GO:0090555 phosphatidylethanolamine flippase activity
GO:0099040 ceramide translocation
GO:1904446 positive regulation of establishment of Sertoli cell barrier

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR011527 ABC transporter type 1, transmembrane domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030258 Multidrug resistance protein 1FamilyFamily
IPR036640 ABC transporter type 1, transmembrane domain superfamilyFamilyHomologous superfamily
IPR039421 Type 1 protein exporterFamilyFamily

Diseases

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Interactions

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