Entity Details

Primary name IL6RA_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP22272
EntryNameIL6RA_MOUSE
FullNameInterleukin-6 receptor subunit alpha
TaxID10090
Evidenceevidence at protein level
Length460
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesIl6ra

GO terms

Show/Hide Table
GOName
GO:0004896 cytokine receptor activity
GO:0004897 ciliary neurotrophic factor receptor activity
GO:0004915 interleukin-6 receptor activity
GO:0004921 interleukin-11 receptor activity
GO:0005138 interleukin-6 receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005896 interleukin-6 receptor complex
GO:0008284 positive regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010536 positive regulation of activation of Janus kinase activity
GO:0010573 vascular endothelial growth factor production
GO:0016324 apical plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0019955 cytokine binding
GO:0019970 interleukin-11 binding
GO:0019981 interleukin-6 binding
GO:0031018 endocrine pancreas development
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032809 neuronal cell body membrane
GO:0032966 negative regulation of collagen biosynthetic process
GO:0034097 response to cytokine
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042803 protein homodimerization activity
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0048589 developmental growth
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070110 ciliary neurotrophic factor receptor complex
GO:0070119 ciliary neurotrophic factor binding
GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0072540 T-helper 17 cell lineage commitment

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015321 Type I cytokine receptor, cytokine-binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink