Entity Details

Primary name HNF1A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP22361
EntryNameHNF1A_MOUSE
FullNameHepatocyte nuclear factor 1-alpha
TaxID10090
Evidenceevidence at protein level
Length628
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesHnf1a

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001221 transcription coregulator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001750 photoreceptor outer segment
GO:0001824 blastocyst development
GO:0001889 liver development
GO:0001890 placenta development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006633 fatty acid biosynthetic process
GO:0006699 bile acid biosynthetic process
GO:0006783 heme biosynthetic process
GO:0006979 response to oxidative stress
GO:0008104 protein localization
GO:0008134 transcription factor binding
GO:0008203 cholesterol metabolic process
GO:0009749 response to glucose
GO:0015721 bile acid and bile salt transport
GO:0015908 fatty acid transport
GO:0016573 histone acetylation
GO:0030073 insulin secretion
GO:0030111 regulation of Wnt signaling pathway
GO:0030326 embryonic limb morphogenesis
GO:0031018 endocrine pancreas development
GO:0032991 protein-containing complex
GO:0035623 renal glucose absorption
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0043691 reverse cholesterol transport
GO:0045120 pronucleus
GO:0045453 bone resorption
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046323 glucose import
GO:0046883 regulation of hormone secretion
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0048341 paraxial mesoderm formation
GO:0048608 reproductive structure development
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060395 SMAD protein signal transduction

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR006897 Hepatocyte nuclear factor 1, beta isoform, C-terminalDomainDomain
IPR006898 Hepatocyte nuclear factor 1, alpha isoform C-terminalDomainDomain
IPR006899 Hepatocyte nuclear factor 1, N-terminalDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR010982 Lambda repressor-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR023219 Hepatocyte nuclear factor 1, N-terminal domain superfamilyFamilyHomologous superfamily
IPR039066 Hepatocyte nuclear factor 1FamilyFamily

Diseases

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Interactions

6 interactions