Entity Details

Primary name MYD88_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP22366
EntryNameMYD88_MOUSE
FullNameMyeloid differentiation primary response protein MyD88
TaxID10090
Evidenceevidence at protein level
Length296
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesMyd88

GO terms

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GOName
GO:0002238 response to molecule of fungal origin
GO:0002269 leukocyte activation involved in inflammatory response
GO:0002283 neutrophil activation involved in immune response
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0005102 signaling receptor binding
GO:0005121 Toll binding
GO:0005149 interleukin-1 receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006909 phagocytosis
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007254 JNK cascade
GO:0008063 Toll signaling pathway
GO:0009615 response to virus
GO:0009682 induced systemic resistance
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0014069 postsynaptic density
GO:0016064 immunoglobulin mediated immune response
GO:0019221 cytokine-mediated signaling pathway
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032481 positive regulation of type I interferon production
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0032675 regulation of interleukin-6 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032722 positive regulation of chemokine production
GO:0032740 positive regulation of interleukin-17 production
GO:0032747 positive regulation of interleukin-23 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0035325 Toll-like receptor binding
GO:0042127 regulation of cell population proliferation
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0042832 defense response to protozoan
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043621 protein self-association
GO:0045087 innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050727 regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060337 type I interferon signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0070944 neutrophil-mediated killing of bacterium
GO:0070976 TIR domain binding
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0090557 establishment of endothelial intestinal barrier
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1902622 regulation of neutrophil migration
GO:2000338 regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR000488 Death domainDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR017281 Myeloid differentiation primary response protein MyD88FamilyFamily
IPR034249 MyD88, death domainDomainDomain
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
MYD88_MOUSEIRAK1_MOUSEBioGRID, DIP, InnateDB, IntAct10854325 15952741 21441935 21743479 22011580 30108181 31930677 details
MYD88_MOUSELRC59_MOUSEIntAct15102471 details
MYD88_MOUSEMYD88_MOUSEBioGRID, IntAct15102471 30108181 details
MYD88_MOUSEUBC9_MOUSEIntAct15102471 details
MYD88_MOUSEP85A_HUMANMINT23247210 details
MYD88_MOUSETLR4_MOUSEBioGRID, InnateDB, UniProt17618294 18772134 19378012 19898473 23023391 29990310 details
MYD88_MOUSEIRAK4_MOUSEBioGRID, DIP, IntAct16306937 19378012 22011580 24529375 30108181 details
MYD88_MOUSETRAF3_MOUSEBioGRID, DIP16306937 19898473 22011580 details
MYD88_MOUSETRAF6_MOUSEBioGRID, DIP16306937 19898473 22011580 30108181 31268348 details
MYD88_MOUSEIRF1_MOUSEDIP17018642 details
MYD88_MOUSEIRF5_MOUSEDIP17018642 details
MYD88_MOUSEIRF7_MOUSEDIP17018642 details
MYD88_MOUSETIRAP_MOUSEBioGRID19378012 30108181 details
MYD88_MOUSEBIRC3_MOUSEBioGRID19898473 details
MYD88_MOUSERNF41_MOUSEBioGRID19483718 details
MYD88_MOUSETLR9_MOUSEBioGRID30108181 details
MYD88_MOUSEIL1R1_MOUSEBioGRID, DIP, IntAct10854325 16477040 17507369 details
MYD88_MOUSECBLB_MOUSEBioGRID, InnateDB17618294 20639876 details
MYD88_MOUSEBTK_MOUSEInnateDB21441935 details
MYD88_MOUSEIRAK1_HUMANIntAct21903422 details
MYD88_MOUSEBCAP_MOUSEUniProt22187460 details
MYD88_MOUSETLR2_MOUSEDIP, UniProt16832055 29990310 details
MYD88_MOUSETNIP1_MOUSEBioGRID, DIP22011580 30108181 details
MYD88_MOUSETLR2_HUMANUniProt29990310 details
MYD88_MOUSELRRF1_MOUSEBioGRID15952741 details
MYD88_MOUSEM3K7_MOUSEBioGRID19898473 details
MYD88_MOUSEBECN1_MOUSEBioGRID18772134 details
MYD88_MOUSEBCL2_MOUSEBioGRID18772134 details
MYD88_MOUSEIRF4_MOUSEBioGRID24670424 details
MYD88_MOUSERN152_HUMANBioGRID31930677 details