Entity Details

Primary name WT1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP22561
EntryNameWT1_MOUSE
FullNameWilms tumor protein homolog
TaxID10090
Evidenceevidence at protein level
Length449
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001570 vasculogenesis
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0003156 regulation of animal organ formation
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0007356 thorax and anterior abdomen determination
GO:0007507 heart development
GO:0007530 sex determination
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0008380 RNA splicing
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0009888 tissue development
GO:0010385 double-stranded methylated DNA binding
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0016607 nuclear speck
GO:0017148 negative regulation of translation
GO:0030308 negative regulation of cell growth
GO:0030317 flagellated sperm motility
GO:0030325 adrenal gland development
GO:0030539 male genitalia development
GO:0030855 epithelial cell differentiation
GO:0032835 glomerulus development
GO:0032836 glomerular basement membrane development
GO:0035802 adrenal cortex formation
GO:0043010 camera-type eye development
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044729 hemi-methylated DNA-binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060009 Sertoli cell development
GO:0060231 mesenchymal to epithelial transition
GO:0060421 positive regulation of heart growth
GO:0060539 diaphragm development
GO:0060923 cardiac muscle cell fate commitment
GO:0060976 coronary vasculature development
GO:0061032 visceral serous pericardium development
GO:0070742 C2H2 zinc finger domain binding
GO:0071371 cellular response to gonadotropin stimulus
GO:0072015 glomerular visceral epithelial cell development
GO:0072075 metanephric mesenchyme development
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0072166 posterior mesonephric tubule development
GO:0072278 metanephric comma-shaped body morphogenesis
GO:0072284 metanephric S-shaped body morphogenesis
GO:0072302 negative regulation of metanephric glomerular mesangial cell proliferation
GO:0072520 seminiferous tubule development
GO:1900212 negative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1905643 positive regulation of DNA methylation
GO:2000020 positive regulation of male gonad development
GO:2000195 negative regulation of female gonad development
GO:2001076 positive regulation of metanephric ureteric bud development

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000976 Wilm's tumour protein, N-terminalDomainDomain
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR017987 Wilm's tumour proteinFamilyFamily
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
WT1_MOUSETET2_MOUSEIntAct25601757 details