Entity Details

Primary name CBL_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP22682
EntryNameCBL_MOUSE
FullNameE3 ubiquitin-protein ligase CBL
TaxID10090
Evidenceevidence at protein level
Length913
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesCbl

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0001784 phosphotyrosine residue binding
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005929 cilium
GO:0006468 protein phosphorylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0008584 male gonad development
GO:0010332 response to gamma radiation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0016567 protein ubiquitination
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0030424 axon
GO:0030426 growth cone
GO:0030971 receptor tyrosine kinase binding
GO:0032487 regulation of Rap protein signal transduction
GO:0033574 response to testosterone
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042594 response to starvation
GO:0043066 negative regulation of apoptotic process
GO:0043303 mast cell degranulation
GO:0045121 membrane raft
GO:0045453 bone resorption
GO:0045471 response to ethanol
GO:0046677 response to antibiotic
GO:0046875 ephrin receptor binding
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048471 perinuclear region of cytoplasm
GO:0061630 ubiquitin protein ligase activity
GO:0070997 neuron death
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0090650 cellular response to oxygen-glucose deprivation
GO:1901215 negative regulation of neuron death
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990782 protein tyrosine kinase binding
GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Golgi apparatus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR003153 Adaptor protein Cbl, N-terminal helicalDomainDomain
IPR009060 UBA-like superfamilyFamilyHomologous superfamily
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR014741 Adaptor protein Cbl, EF hand-likeDomainDomain
IPR014742 Adaptor protein Cbl, SH2-like domainDomainDomain
IPR015940 Ubiquitin-associated domainDomainDomain
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR024159 Adaptor protein Cbl, PTB domainDomainDomain
IPR024162 Adaptor protein CblFamilyFamily
IPR036537 Adaptor protein Cbl, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR039520 E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclassDomainDomain

Diseases

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Interactions

59 interactions

InteractorPartnerSourcesPublicationsLink
CBL_MOUSECD2AP_MOUSEBioGRID, IntAct, MINT12559036 15001553 27474268 details
CBL_MOUSEEGFR_MOUSEBioGRID, MINT14691459 17139251 17372273 20298671 23027125 23457600 23799367 32325033 7657591 details
CBL_MOUSECRKL_MOUSEBioGRID, IntAct10391678 11031258 11069064 11804588 27474268 32325033 8978305 9067577 details
CBL_MOUSESRC_MOUSEBioGRID, DIP11804588 17420256 22138575 32325033 8635998 8849724 9013636 details
CBL_MOUSEPGFRB_MOUSEBioGRID15753096 17620338 18814181 details
CBL_MOUSESH2B2_MOUSEBioGRID10854852 11997497 20298671 9989826 details
CBL_MOUSEZAP70_MOUSEBioGRID20298671 8551236 details
CBL_MOUSEHCK_MOUSEBioGRID10799548 12032836 9890970 details
CBL_MOUSEABL1_MOUSEBioGRID10391678 8635998 9393882 details
CBL_MOUSESRBS2_MOUSEBioGRID20886612 details
CBL_MOUSEPAXI_MOUSEBioGRID8641358 details
CBL_MOUSEITB1_MOUSEBioGRID30333137 details
CBL_MOUSEITB3_MOUSEBioGRID30333137 details
CBL_MOUSEGRB2_MOUSEBioGRID, IntAct17372273 21703542 21725061 23452850 27474268 32325033 7657591 8635998 9174058 details
CBL_MOUSEEGFR_HUMANBioGRID, IntAct19263517 31260484 7657591 details
CBL_MOUSEVGFR1_MOUSEBioGRID, MINT15001553 17962812 details
CBL_MOUSEITSN1_MOUSEBioGRID, MINT16914641 17875942 21712076 details
CBL_MOUSEFYN_MOUSEBioGRID, IntAct, MINT19734451 27474268 8551236 8635998 9210408 9890970 details
CBL_MOUSEITSN1_HUMANMINT18539136 details
CBL_MOUSECRK_MOUSEBioGRID, IntAct10633073 11069064 11997497 15581361 15581362 20697350 27474268 32325033 8635998 9013636 9210408 9447983 details
CBL_MOUSEDDX58_MOUSEIntAct23374343 details
CBL_MOUSEPTN11_MOUSEBioGRID, IntAct23374343 32325033 9393882 details
CBL_MOUSEMET_MOUSEMINT24440350 details
CBL_MOUSEHCK_HUMANIntAct10092522 details
CBL_MOUSESH3K1_MOUSEBioGRID, IntAct21725061 27474268 32325033 details
CBL_MOUSEP85A_MOUSEBioGRID, IntAct10391678 10633073 10799548 10940298 11406619 15581361 15581362 16798838 17420256 20133944 27474268 32325033 8947469 9013636 9115297 9174058 9890970 details
CBL_MOUSECBLB_MOUSEBioGRID, IntAct12102152 27474268 details
CBL_MOUSECD5_MOUSEIntAct27474268 details
CBL_MOUSESHIP1_MOUSEBioGRID, IntAct16601135 27474268 9393882 details
CBL_MOUSEPLCG1_MOUSEBioGRID, IntAct27474268 32325033 7517397 details
CBL_MOUSELCK_MOUSEBioGRID11741956 8551236 9115297 details
CBL_MOUSEKIT_MOUSEBioGRID19734451 details
CBL_MOUSEKSYK_HUMANBioGRID19419964 details
CBL_MOUSENEDD4_MOUSEBioGRID18931680 details
CBL_MOUSENCK1_MOUSEBioGRID32325033 7517397 8635998 details
CBL_MOUSEFGR_MOUSEBioGRID7517397 9687507 details
CBL_MOUSESPTA1_MOUSEBioGRID7517397 details
CBL_MOUSEEPS8_MOUSEBioGRID7517397 details
CBL_MOUSETNR11_MOUSEBioGRID11406619 details
CBL_MOUSETNR5_MOUSEBioGRID11406619 details
CBL_MOUSETRAF6_MOUSEBioGRID11406619 details
CBL_MOUSESRBS1_MOUSEBioGRID11997497 12765336 9447983 details
CBL_MOUSELYN_MOUSEBioGRID8627181 8635998 9687507 9890970 details
CBL_MOUSEMLP3B_MOUSEBioGRID22138575 details
CBL_MOUSEDOK3_MOUSEBioGRID21703542 details
CBL_MOUSEERBB2_MOUSEBioGRID10940298 details
CBL_MOUSESH3K1_HUMANBioGRID21725061 details
CBL_MOUSEPK3CG_MOUSEBioGRID9115297 details
CBL_MOUSEITK_MOUSEBioGRID20670954 details
CBL_MOUSEKSYK_MOUSEBioGRID20670954 details
CBL_MOUSESYNEM_MOUSEBioGRID15872089 32325033 details
CBL_MOUSESLAP2_MOUSEBioGRID12024036 details
CBL_MOUSESLAP1_MOUSEBioGRID12024036 details
CBL_MOUSEDLG1_MOUSEBioGRID15699074 details
CBL_MOUSECSF1R_MOUSEBioGRID17420256 32325033 details
CBL_MOUSEATX2_MOUSEBioGRID18602463 details
CBL_MOUSETNFA_MOUSEBioGRID29891719 details
CBL_MOUSETGFR2_MOUSEBioGRID31315051 details
CBL_MOUSEATM_MOUSEBioGRID31315051 details