Entity Details

Primary name WNT4_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP22724
EntryNameWNT4_MOUSE
FullNameProtein Wnt-4
TaxID10090
Evidenceevidence at protein level
Length351
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesWnt4

GO terms

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GOName
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001823 mesonephros development
GO:0001837 epithelial to mesenchymal transition
GO:0001838 embryonic epithelial tube formation
GO:0001889 liver development
GO:0003714 transcription corepressor activity
GO:0005102 signaling receptor binding
GO:0005109 frizzled binding
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007276 gamete generation
GO:0007548 sex differentiation
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0009267 cellular response to starvation
GO:0009986 cell surface
GO:0010629 negative regulation of gene expression
GO:0010894 negative regulation of steroid biosynthetic process
GO:0022407 regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030237 female sex determination
GO:0030325 adrenal gland development
GO:0030336 negative regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0031012 extracellular matrix
GO:0032349 positive regulation of aldosterone biosynthetic process
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033077 T cell differentiation in thymus
GO:0033080 immature T cell proliferation in thymus
GO:0035239 tube morphogenesis
GO:0035567 non-canonical Wnt signaling pathway
GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042445 hormone metabolic process
GO:0043547 positive regulation of GTPase activity
GO:0045165 cell fate commitment
GO:0045596 negative regulation of cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045836 positive regulation of meiotic nuclear division
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048018 receptor ligand activity
GO:0048599 oocyte development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048856 anatomical structure development
GO:0051145 smooth muscle cell differentiation
GO:0051496 positive regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0060070 canonical Wnt signaling pathway
GO:0060126 somatotropin secreting cell differentiation
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation
GO:0060231 mesenchymal to epithelial transition
GO:0060748 tertiary branching involved in mammary gland duct morphogenesis
GO:0060993 kidney morphogenesis
GO:0061045 negative regulation of wound healing
GO:0061184 positive regulation of dermatome development
GO:0061205 paramesonephric duct development
GO:0061369 negative regulation of testicular blood vessel morphogenesis
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072006 nephron development
GO:0072033 renal vesicle formation
GO:0072034 renal vesicle induction
GO:0072162 metanephric mesenchymal cell differentiation
GO:0072164 mesonephric tubule development
GO:0072174 metanephric tubule formation
GO:0072210 metanephric nephron development
GO:0072273 metanephric nephron morphogenesis
GO:2000019 negative regulation of male gonad development
GO:2000066 positive regulation of cortisol biosynthetic process
GO:2000180 negative regulation of androgen biosynthetic process
GO:2000225 negative regulation of testosterone biosynthetic process
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR005817 WntFamilyFamily
IPR009142 Wnt-4 proteinFamilyFamily
IPR018161 Wnt protein, conserved siteSiteConserved site
IPR043158 Wnt, C-terminal domainFamilyHomologous superfamily

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
WNT4_MOUSEWIF1_HUMANMINT22986341 details
WNT4_MOUSEKLOT_MOUSEIntAct17690294 details
WNT4_MOUSEPORCN_MOUSEBioGRID, UniProt10866835 details