Entity Details

Primary name PAI1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP22777
EntryNamePAI1_MOUSE
FullNamePlasminogen activator inhibitor 1
TaxID10090
Evidenceevidence at protein level
Length402
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0001890 placenta development
GO:0002020 protease binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0008585 female gonad development
GO:0010469 regulation of signaling receptor activity
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010757 negative regulation of plasminogen activation
GO:0010951 negative regulation of endopeptidase activity
GO:0014912 negative regulation of smooth muscle cell migration
GO:0030194 positive regulation of blood coagulation
GO:0030336 negative regulation of cell migration
GO:0032757 positive regulation of interleukin-8 production
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0035491 positive regulation of leukotriene production involved in inflammatory response
GO:0035690 cellular response to drug
GO:0042127 regulation of cell population proliferation
GO:0042583 chromaffin granule
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0048146 positive regulation of fibroblast proliferation
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0050729 positive regulation of inflammatory response
GO:0050820 positive regulation of coagulation
GO:0050829 defense response to Gram-negative bacterium
GO:0051549 positive regulation of keratinocyte migration
GO:0051918 negative regulation of fibrinolysis
GO:0061044 negative regulation of vascular wound healing
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090280 positive regulation of calcium ion import
GO:0090399 replicative senescence
GO:0097187 dentinogenesis
GO:1901331 positive regulation of odontoblast differentiation
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1905043 positive regulation of epithelium regeneration
GO:2000098 negative regulation of smooth muscle cell-matrix adhesion
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000215 Serpin familyFamilyFamily
IPR023795 Serpin, conserved siteSiteConserved site
IPR023796 Serpin domainDomainDomain
IPR036186 Serpin superfamilyFamilyHomologous superfamily
IPR042178 Serpin superfamily, domain 1FamilyHomologous superfamily
IPR042185 Serpin superfamily, domain 2FamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PAI1_MOUSETM11E_MOUSEIntAct15328353 details