Entity Details

Primary name PPARA_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP23204
EntryNamePPARA_MOUSE
FullNamePeroxisome proliferator-activated receptor alpha
TaxID10090
Evidenceevidence at protein level
Length468
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesPpara

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001223 transcription coactivator binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001666 response to hypoxia
GO:0003700 DNA-binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006006 glucose metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0008289 lipid binding
GO:0008544 epidermis development
GO:0009267 cellular response to starvation
GO:0009755 hormone-mediated signaling pathway
GO:0010468 regulation of gene expression
GO:0010565 regulation of cellular ketone metabolic process
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010876 lipid localization
GO:0010887 negative regulation of cholesterol storage
GO:0010891 negative regulation of sequestering of triglyceride
GO:0019216 regulation of lipid metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0019902 phosphatase binding
GO:0019904 protein domain specific binding
GO:0030154 cell differentiation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031624 ubiquitin conjugating enzyme binding
GO:0032091 negative regulation of protein binding
GO:0032099 negative regulation of appetite
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0033993 response to lipid
GO:0035095 behavioral response to nicotine
GO:0038023 signaling receptor activity
GO:0042060 wound healing
GO:0042157 lipoprotein metabolic process
GO:0042752 regulation of circadian rhythm
GO:0043565 sequence-specific DNA binding
GO:0044877 protein-containing complex binding
GO:0045070 positive regulation of viral genome replication
GO:0045471 response to ethanol
GO:0045722 positive regulation of gluconeogenesis
GO:0045776 negative regulation of blood pressure
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045923 positive regulation of fatty acid metabolic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046321 positive regulation of fatty acid oxidation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0050728 negative regulation of inflammatory response
GO:0051525 NFAT protein binding
GO:0051898 negative regulation of protein kinase B signaling
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
GO:0070166 enamel mineralization
GO:0097371 MDM2/MDM4 family protein binding
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1901215 negative regulation of neuron death
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903944 negative regulation of hepatocyte apoptotic process
GO:2000272 negative regulation of signaling receptor activity
GO:2001171 positive regulation of ATP biosynthetic process

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003074 Peroxisome proliferator-activated receptorFamilyFamily
IPR003076 Peroxisome proliferator-activated receptor alphaFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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