Entity Details

Primary name MDM2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP23804
EntryNameMDM2_MOUSE
FullNameE3 ubiquitin-protein ligase Mdm2
TaxID10090
Evidenceevidence at protein level
Length489
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesMdm2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001568 blood vessel development
GO:0001974 blood vessel remodeling
GO:0002027 regulation of heart rate
GO:0002039 p53 binding
GO:0003170 heart valve development
GO:0003181 atrioventricular valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003281 ventricular septum development
GO:0003283 atrial septum development
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007089 traversing start control point of mitotic cell cycle
GO:0007507 heart development
GO:0008097 5S rRNA binding
GO:0008270 zinc ion binding
GO:0009636 response to toxic substance
GO:0010039 response to iron ion
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010955 negative regulation of protein processing
GO:0010977 negative regulation of neuron projection development
GO:0016567 protein ubiquitination
GO:0016874 ligase activity
GO:0019789 SUMO transferase activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0031648 protein destabilization
GO:0032026 response to magnesium ion
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032991 protein-containing complex
GO:0033612 receptor serine/threonine kinase binding
GO:0034504 protein localization to nucleus
GO:0042176 regulation of protein catabolic process
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043021 ribonucleoprotein complex binding
GO:0043066 negative regulation of apoptotic process
GO:0043130 ubiquitin binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043278 response to morphine
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045184 establishment of protein localization
GO:0045202 synapse
GO:0045472 response to ether
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046827 positive regulation of protein export from nucleus
GO:0047485 protein N-terminus binding
GO:0048545 response to steroid hormone
GO:0051149 positive regulation of muscle cell differentiation
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0051865 protein autoubiquitination
GO:0060411 cardiac septum morphogenesis
GO:0061630 ubiquitin protein ligase activity
GO:0061663 NEDD8 ligase activity
GO:0065003 protein-containing complex assembly
GO:0070301 cellular response to hydrogen peroxide
GO:0071301 cellular response to vitamin B1
GO:0071312 cellular response to alkaloid
GO:0071363 cellular response to growth factor stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0071391 cellular response to estrogen stimulus
GO:0071480 cellular response to gamma radiation
GO:0071494 cellular response to UV-C
GO:0072717 cellular response to actinomycin D
GO:0097718 disordered domain specific binding
GO:1901797 negative regulation of signal transduction by p53 class mediator
GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1904404 response to formaldehyde
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1990000 amyloid fibril formation
GO:1990785 response to water-immersion restraint stress

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR001876 Zinc finger, RanBP2-typeDomainDomain
IPR003121 SWIB/MDM2 domainDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR015459 Ubiquitin-protein ligase E3 MDM2FamilyFamily
IPR016495 p53 negative regulator Mdm2/Mdm4FamilyFamily
IPR028340 E3 ubiquitin-protein ligase Mdm2FamilyFamily
IPR036443 Zinc finger, RanBP2-type superfamilyFamilyHomologous superfamily
IPR036885 SWIB/MDM2 domain superfamilyFamilyHomologous superfamily
IPR044080 MDM2, modified RING finger, HC subclassDomainDomain

Diseases

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Interactions

59 interactions

InteractorPartnerSourcesPublicationsLink
MDM2_MOUSEARRB1_MOUSEIntAct15102471 details
MDM2_MOUSEP53_MOUSEBioGRID, DIP, I2D, IntAct10205143 10706102 10982879 11953423 14555661 17086174 17936560 18309296 18359851 18566590 18695251 19556538 20697359 20818388 20832751 21183956 21738215 21857681 22216266 22666487 22805162 23580573 25117711 25732823 30545932 30578299 8058315 9732264 details
MDM2_MOUSERASF1_MOUSEBioGRID, MINT18566590 details
MDM2_MOUSEP53_HUMANBioGRID, MINT10202144 11983168 18566590 24980433 details
MDM2_MOUSEPLK1_HUMANBioGRID, MINT19833129 details
MDM2_MOUSEMDM4_MOUSEBioGRID, DIP, I2D, IntAct17616658 19573810 20697359 21730132 22666487 25117711 25981963 details
MDM2_MOUSEARF_MOUSEBioGRID, IntAct10713175 15485902 20832751 22378045 23580573 details
MDM2_MOUSERASF5_MOUSEMINT22173032 details
MDM2_MOUSEMDM2_MOUSEBioGRID17086174 18566590 details
MDM2_MOUSEPAX3_MOUSEBioGRID22216266 details
MDM2_MOUSESENP2_MOUSEBioGRID21183956 details
MDM2_MOUSEUBC9_MOUSEBioGRID21183956 details
MDM2_MOUSECDN2A_MOUSEBioGRID10713175 15485902 20832751 22378045 23580573 details
MDM2_MOUSENUMB_HUMANBioGRID9632782 details
MDM2_MOUSEDPOE1_HUMANBioGRID10982879 details
MDM2_MOUSEDPOE1_MOUSEBioGRID10982879 details
MDM2_MOUSECCNG1_MOUSEBioGRID11983168 details
MDM2_MOUSECDK2_HUMANBioGRID11983168 details
MDM2_MOUSEPP2AA_HUMANBioGRID11983168 details
MDM2_MOUSEUB2D3_MOUSEBioGRID22216266 details
MDM2_MOUSEUB2D1_MOUSEBioGRID21183956 details
MDM2_MOUSECEBPB_MOUSEBioGRID25720496 details
MDM2_MOUSEPP2AA_MOUSEBioGRID28025327 details
MDM2_MOUSERL5_MOUSEIntAct17936560 20832751 22789538 details
MDM2_MOUSERL11_MOUSEBioGRID, IntAct15989966 17936560 20832751 22789538 details
MDM2_MOUSEUBB_MOUSEDIP, IntAct17936560 21730132 details
MDM2_MOUSEUBC_MOUSEDIP, IntAct17936560 21730132 details
MDM2_MOUSERS27A_MOUSEDIP, IntAct17936560 21730132 details
MDM2_MOUSERL40_MOUSEDIP, IntAct17936560 21730132 details
MDM2_MOUSEDAXX_MOUSEBioGRID, MINT15364927 18566590 details
MDM2_MOUSE1433T_MOUSEMINT20086099 details
MDM2_MOUSERL23_MOUSEBioGRID, IntAct20832751 details
MDM2_MOUSEKS6B1_MOUSEMINT20657550 details
MDM2_MOUSEUBP7_HUMANBioGRID, I2D20697359 29581288 details
MDM2_MOUSEHIPK1_MOUSEBioGRID, MINT22173032 details
MDM2_MOUSEDLG4_MOUSEBioGRID, IntAct21849563 23260144 30292394 details
MDM2_MOUSEEF1A1_MOUSEIntAct23260144 details
MDM2_MOUSESUMO1_MOUSEDIP19090619 details
MDM2_MOUSEP73_MOUSEDIP20921405 details
MDM2_MOUSERB_HUMANDIP7791904 details
MDM2_MOUSEHDAC1_MOUSEMINT29950602 details
MDM2_MOUSEFOXO3_MOUSEBioGRID22094330 details
MDM2_MOUSEUBP7_MOUSEBioGRID18566590 20697359 details
MDM2_MOUSEARRB2_HUMANBioGRID19372219 details
MDM2_MOUSEIGF1R_MOUSEBioGRID15878855 details
MDM2_MOUSENBN_MOUSEBioGRID15734743 details
MDM2_MOUSEMRE11_MOUSEBioGRID15734743 details
MDM2_MOUSEARBK1_MOUSEBioGRID21081496 details
MDM2_MOUSEELAV1_MOUSEBioGRID22095636 details
MDM2_MOUSEGSK3B_MOUSEBioGRID21738215 details
MDM2_MOUSENECD_MOUSEBioGRID22905258 details
MDM2_MOUSECCAR1_MOUSEBioGRID22905258 details
MDM2_MOUSEEID1_MOUSEBioGRID24167073 details
MDM2_MOUSEARRB2_MOUSEBioGRID11588219 details
MDM2_MOUSEDDX24_HUMANBioGRID24980433 details
MDM2_MOUSEEZH2_MOUSEBioGRID26748827 details
MDM2_MOUSESP1_MOUSEBioGRID22378045 details
MDM2_MOUSEDLG2_MOUSEBioGRID30292394 details
MDM2_MOUSEIRS1_HUMANBioGRID30578299 details