Entity Details

Primary name ITAL_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP24063
EntryNameITAL_MOUSE
FullNameIntegrin alpha-L
TaxID10090
Evidenceevidence at protein level
Length1163
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0001772 immunological synapse
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0005911 cell-cell junction
GO:0006909 phagocytosis
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0030369 ICAM-3 receptor activity
GO:0034687 integrin alphaL-beta2 complex
GO:0035683 memory T cell extravasation
GO:0042102 positive regulation of T cell proliferation
GO:0043113 receptor clustering
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0050798 activated T cell proliferation
GO:0050839 cell adhesion molecule binding
GO:0050850 positive regulation of calcium-mediated signaling
GO:0098609 cell-cell adhesion

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR002035 von Willebrand factor, type ADomainDomain
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ITAL_MOUSERASF5_MOUSEUniProt12845325 details
ITAL_MOUSEITB2_MOUSEDIP17785425 details