Entity Details

Primary name MED25_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ71SY5
EntryNameMED25_HUMAN
FullNameMediator of RNA polymerase II transcription subunit 25
TaxID9606
Evidenceevidence at protein level
Length747
SequenceStatuscomplete
DateCreated2007-10-02
DateModified2021-06-02

Ontological Relatives

GenesMED25

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001223 transcription coactivator binding
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0008134 transcription factor binding
GO:0016592 mediator complex
GO:0035563 positive regulation of chromatin binding
GO:0042974 retinoic acid receptor binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046965 retinoid X receptor binding
GO:0048147 negative regulation of fibroblast proliferation
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:2001178 positive regulation of mediator complex assembly

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR021394 Mediator complex, subunit Med25, PTOV domainDomainDomain
IPR021397 Mediator complex, subunit Med25, synapsin 1DomainDomain
IPR021406 Mediator complex, subunit Med25, NR boxDomainDomain
IPR021419 Mediator of RNA polymerase II transcription subunit 25, von Willebrand factor type A domainDomainDomain
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily
IPR038196 Mediator complex subunit 25, PTOV domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MED25_HUMANRXRA_MOUSEMINT17641689 details