Entity Details

Primary name MARK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ7KZI7
EntryNameMARK2_HUMAN
FullNameSerine/threonine-protein kinase MARK2
TaxID9606
Evidenceevidence at protein level
Length788
SequenceStatuscomplete
DateCreated2005-04-12
DateModified2021-06-02

Ontological Relatives

GenesMARK2

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001764 neuron migration
GO:0003723 RNA binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0016020 membrane
GO:0016055 Wnt signaling pathway
GO:0018105 peptidyl-serine phosphorylation
GO:0030010 establishment of cell polarity
GO:0032147 activation of protein kinase activity
GO:0046777 protein autophosphorylation
GO:0048156 tau protein binding
GO:0050321 tau-protein kinase activity
GO:0051493 regulation of cytoskeleton organization
GO:0000226 microtubule cytoskeleton organization
GO:0005739 mitochondrion
GO:0005884 actin filament
GO:0008289 lipid binding
GO:0010976 positive regulation of neuron projection development
GO:0018107 peptidyl-threonine phosphorylation
GO:0030295 protein kinase activator activity
GO:0030425 dendrite
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0061564 axon development
GO:1904526 regulation of microtubule binding
GO:0000422 autophagy of mitochondrion
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0035556 intracellular signal transduction
GO:0045296 cadherin binding
GO:0050770 regulation of axonogenesis
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0097427 microtubule bundle
GO:0106310 protein serine kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0016328 lateral plasma membrane
GO:0051646 mitochondrion localization
GO:0071963 establishment or maintenance of cell polarity regulating cell shape
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Lateral cell membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001772 Kinase associated domain 1 (KA1)DomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015940 Ubiquitin-associated domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR028375 KA1 domain/Ssp2, C-terminalFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MARK2_HUMANCRTC2_MOUSEBioGRID, DIP18626018 details
MARK2_HUMANMIME_MOUSEmatrixdb20375348 details