Entity Details

Primary name TNR1A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP25118
EntryNameTNR1A_MOUSE
FullNameTumor necrosis factor receptor superfamily member 1A
TaxID10090
Evidenceevidence at protein level
Length454
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesTnfrsf1a

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0002020 protease binding
GO:0003176 aortic valve development
GO:0003177 pulmonary valve development
GO:0003332 negative regulation of extracellular matrix constituent secretion
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006693 prostaglandin metabolic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009986 cell surface
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016021 integral component of membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0030424 axon
GO:0032715 negative regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042307 positive regulation of protein import into nucleus
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043120 tumor necrosis factor binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0043525 positive regulation of neuron apoptotic process
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0071260 cellular response to mechanical stimulus
GO:0072659 protein localization to plasma membrane
GO:1902339 positive regulation of apoptotic process involved in morphogenesis
GO:1903140 regulation of establishment of endothelial barrier

Subcellular Location

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Subcellular Location
Cell membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR001368 TNFR/NGFR cysteine-rich regionDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR020419 Tumour necrosis factor receptor 1AFamilyFamily
IPR033993 Tumor necrosis factor receptor 1A, N-terminalDomainDomain
IPR033994 Tumor necrosis factor receptor 1A, death domainDomainDomain

Diseases

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Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
TNR1A_MOUSETRADD_HUMANBioGRID, HPIDb, IntAct11374864 7758105 details
TNR1A_MOUSEGTR1_MOUSEIntAct15102471 details
TNR1A_MOUSEEHMT2_MOUSEIntAct15102471 details
TNR1A_MOUSEDCOR_MOUSEIntAct15102471 details
TNR1A_MOUSEFBLN2_MOUSEIntAct15102471 details
TNR1A_MOUSEATRAP_MOUSEIntAct15102471 details
TNR1A_MOUSEVAPA_MOUSEIntAct15102471 details
TNR1A_MOUSESL9A1_MOUSEIntAct15102471 details
TNR1A_MOUSESON_MOUSEIntAct15102471 details
TNR1A_MOUSES39A7_MOUSEIntAct15102471 details
TNR1A_MOUSESC61B_MOUSEIntAct15102471 details
TNR1A_MOUSERN111_MOUSEIntAct15102471 details
TNR1A_MOUSETNFA_MOUSEBioGRID, IntAct11448951 18022363 18621737 24469399 29203883 29891719 30420664 details
TNR1A_MOUSETNFA_HUMANBioGRID, DIP11448951 26649818 details
TNR1A_MOUSEBABA2_MOUSEBioGRID9737713 details
TNR1A_MOUSEMK01_MOUSEBioGRID15865443 details
TNR1A_MOUSECALX_MOUSEMINT16680093 details
TNR1A_MOUSEERN1_MOUSEMINT16680093 details
TNR1A_MOUSERIPK1_MOUSEBioGRID, DIP, IntAct, MINT16547522 16680093 18022363 18719121 23602765 29203883 29891719 30209212 details
TNR1A_MOUSESYK_MOUSEIntAct16291755 details
TNR1A_MOUSEVTI1B_MOUSEMINT21157428 details
TNR1A_MOUSEUBB_MOUSEDIP26649818 details
TNR1A_MOUSEUBC_MOUSEDIP26649818 details
TNR1A_MOUSERS27A_MOUSEDIP26649818 details
TNR1A_MOUSERL40_MOUSEDIP26649818 details
TNR1A_MOUSEFADD_MOUSEDIP26649818 details
TNR1A_MOUSEIRAK1_MOUSEBioGRID18562480 details
TNR1A_MOUSEIKKB_MOUSEBioGRID16547522 29891719 32325033 details
TNR1A_MOUSENEMO_MOUSEBioGRID16547522 details
TNR1A_MOUSEFEM1B_HUMANBioGRID10542291 details
TNR1A_MOUSEKSYK_MOUSEBioGRID16291755 details
TNR1A_MOUSETNAP3_MOUSEBioGRID23602765 29203883 29891719 30209212 32325033 details
TNR1A_MOUSERNF31_MOUSEBioGRID24461064 29203883 32325033 details
TNR1A_MOUSETNIP1_MOUSEBioGRID29203883 details
TNR1A_MOUSESHRPN_MOUSEBioGRID29203883 details
TNR1A_MOUSECY24A_MOUSEBioGRID19641494 details