Entity Details

Primary name NFKB1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP25799
EntryNameNFKB1_MOUSE
FullNameNuclear factor NF-kappa-B p105 subunit
TaxID10090
Evidenceevidence at protein level
Length971
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesNfkb1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001818 negative regulation of cytokine production
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0007165 signal transduction
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010956 negative regulation of calcidiol 1-monooxygenase activity
GO:0014070 response to organic cyclic compound
GO:0019899 enzyme binding
GO:0031072 heat shock protein binding
GO:0032695 negative regulation of interleukin-12 production
GO:0032991 protein-containing complex
GO:0035994 response to muscle stretch
GO:0042802 identical protein binding
GO:0042805 actinin binding
GO:0043005 neuron projection
GO:0043066 negative regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044877 protein-containing complex binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048535 lymph node development
GO:0050728 negative regulation of inflammatory response
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071316 cellular response to nicotine
GO:0071322 cellular response to carbohydrate stimulus
GO:0071345 cellular response to cytokine stimulus
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071359 cellular response to dsRNA
GO:0071407 cellular response to organic cyclic compound
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:1901653 cellular response to peptide
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904385 cellular response to angiotensin
GO:1904630 cellular response to diterpene
GO:1904632 cellular response to glucoside
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
GO:2000630 positive regulation of miRNA metabolic process
GO:2000637 positive regulation of gene silencing by miRNA

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000451 NF-kappa-B/DorsalFamilyFamily
IPR000488 Death domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR002909 IPT domainDomainDomain
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR011539 Rel homology domain (RHD), DNA-binding domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR030492 Rel homology domain, conserved siteSiteConserved site
IPR030503 Nuclear factor NF-kappa-B, p105 subunitFamilyFamily
IPR032397 Rel homology dimerisation domainDomainDomain
IPR033926 NFkappaB IPT domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily
IPR037059 Rel homology domain (RHD), DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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