Entity Details

Primary name MGMT_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP26187
EntryNameMGMT_MOUSE
FullNameMethylated-DNA--protein-cysteine methyltransferase
TaxID10090
Evidenceevidence at protein level
Length211
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesMgmt

GO terms

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GOName
GO:0003677 DNA binding
GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO:0005509 calcium ion binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006281 DNA repair
GO:0006307 DNA dealkylation involved in DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0008168 methyltransferase activity
GO:0009636 response to toxic substance
GO:0032259 methylation
GO:0034599 cellular response to oxidative stress
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045471 response to ethanol
GO:0045739 positive regulation of DNA repair
GO:0051593 response to folic acid
GO:0060548 negative regulation of cell death
GO:0060644 mammary gland epithelial cell differentiation
GO:0071407 cellular response to organic cyclic compound
GO:0071479 cellular response to ionizing radiation
GO:2000781 positive regulation of double-strand break repair

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active siteSiteActive site
IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domainDomainDomain
IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA bindingDomainDomain
IPR036217 Methylated DNA-protein cysteine methyltransferase, DNA binding domainFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036631 Methylated DNA-protein cysteine methyltransferase domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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