Entity Details

Primary name HUWE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ7Z6Z7
EntryNameHUWE1_HUMAN
FullNameE3 ubiquitin-protein ligase HUWE1
TaxID9606
Evidenceevidence at protein level
Length4374
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesHUWE1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000209 protein polyubiquitination
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006284 base-excision repair
GO:0006513 protein monoubiquitination
GO:0007030 Golgi organization
GO:0010637 negative regulation of mitochondrial fusion
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0016574 histone ubiquitination
GO:0030154 cell differentiation
GO:0031398 positive regulation of protein ubiquitination
GO:0032922 circadian regulation of gene expression
GO:0034774 secretory granule lumen
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043312 neutrophil degranulation
GO:0045732 positive regulation of protein catabolic process
GO:0061025 membrane fusion
GO:0061630 ubiquitin protein ligase activity
GO:0070062 extracellular exosome
GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000569 HECT domainDomainDomain
IPR004170 WWE domainDomainDomain
IPR009060 UBA-like superfamilyFamilyHomologous superfamily
IPR010309 E3 ubiquitin ligase, domain of unknown function DUF908DomainDomain
IPR010314 E3 ubiquitin ligase, domain of unknown function DUF913DomainDomain
IPR015940 Ubiquitin-associated domainDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR025527 HUWE1/Rev1, ubiquitin binding regionRepeatRepeat
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR037197 WWE domain superfamilyFamilyHomologous superfamily
IPR041918 HUWE1, UBA domainDomainDomain

Diseases

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Interactions

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