Entity Details

Primary name P85A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP26450
EntryNameP85A_MOUSE
FullNamePhosphatidylinositol 3-kinase regulatory subunit alpha
TaxID10090
Evidenceevidence at protein level
Length724
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPik3r1

GO terms

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GOName
GO:0001678 cellular glucose homeostasis
GO:0001784 phosphotyrosine residue binding
GO:0001934 positive regulation of protein phosphorylation
GO:0001953 negative regulation of cell-matrix adhesion
GO:0005102 signaling receptor binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005516 calmodulin binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005801 cis-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
GO:0006006 glucose metabolic process
GO:0006468 protein phosphorylation
GO:0006606 protein import into nucleus
GO:0007162 negative regulation of cell adhesion
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008286 insulin receptor signaling pathway
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010459 negative regulation of heart rate
GO:0010592 positive regulation of lamellipodium assembly
GO:0010628 positive regulation of gene expression
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0022408 negative regulation of cell-cell adhesion
GO:0030183 B cell differentiation
GO:0030331 estrogen receptor binding
GO:0030335 positive regulation of cell migration
GO:0030971 receptor tyrosine kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0033120 positive regulation of RNA splicing
GO:0034644 cellular response to UV
GO:0034976 response to endoplasmic reticulum stress
GO:0035014 phosphatidylinositol 3-kinase regulator activity
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
GO:0042307 positive regulation of protein import into nucleus
GO:0043005 neuron projection
GO:0043066 negative regulation of apoptotic process
GO:0043125 ErbB-3 class receptor binding
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0043559 insulin binding
GO:0043560 insulin receptor substrate binding
GO:0045663 positive regulation of myoblast differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045776 negative regulation of blood pressure
GO:0045861 negative regulation of proteolysis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
GO:0046982 protein heterodimerization activity
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050821 protein stabilization
GO:0051117 ATPase binding
GO:0051219 phosphoprotein binding
GO:0051384 response to glucocorticoid
GO:0051491 positive regulation of filopodium assembly
GO:0051492 regulation of stress fiber assembly
GO:0051497 negative regulation of stress fiber assembly
GO:0051591 response to cAMP
GO:0051965 positive regulation of synapse assembly
GO:0060396 growth hormone receptor signaling pathway
GO:0120183 positive regulation of focal adhesion disassembly
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1903076 regulation of protein localization to plasma membrane
GO:1990578 perinuclear endoplasmic reticulum membrane

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000198 Rho GTPase-activating protein domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR032498 PI3K regulatory subunit p85-related , inter-SH2 domainDomainDomain
IPR035020 PI3K p85 subunit, C-terminal SH2 domainDomainDomain
IPR035022 PI3K p85 subunit, N-terminal SH2 domainDomainDomain
IPR035591 Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR044124 PIK3R1, inter-SH2 domainDomainDomain

Diseases

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Interactions

71 interactions

InteractorPartnerSourcesPublicationsLink
P85A_MOUSECTNB1_MOUSEBioGRID, IntAct15102471 32325033 details
P85A_MOUSEBRD7_MOUSEIntAct15102471 details
P85A_MOUSEPK3CA_MOUSEBioGRID, DIP, IntAct15102471 18449193 24651434 8947469 details
P85A_MOUSESH3G1_MOUSEBioGRID, IntAct15102471 32325033 details
P85A_MOUSEPK3CB_MOUSEBioGRID, DIP, IntAct15102471 18449193 32325033 details
P85A_MOUSEPK3CD_MOUSEI2D, IntAct15102471 22020336 details
P85A_MOUSEGOGA3_MOUSEIntAct15102471 details
P85A_MOUSEIF4G2_MOUSEIntAct15102471 details
P85A_MOUSEPCBP2_MOUSEIntAct15102471 details
P85A_MOUSENDKB_MOUSEIntAct15102471 details
P85A_MOUSECBL_HUMANBioGRID, MINT9174058 9414268 details
P85A_MOUSETIE2_MOUSEBioGRID, MINT10521483 9632797 details
P85A_MOUSEGRB2_MOUSEBioGRID10995764 32325033 9174058 details
P85A_MOUSECSF1R_MOUSEBioGRID10330148 17420256 32325033 8947469 9312046 details
P85A_MOUSELCK_MOUSEBioGRID9115297 details
P85A_MOUSEKIT_MOUSEBioGRID10679268 1370584 22378847 details
P85A_MOUSEGAB1_MOUSEBioGRID11896055 12808090 19401591 details
P85A_MOUSECRKL_MOUSEBioGRID11031258 details
P85A_MOUSEABI1_MOUSEBioGRID12515821 details
P85A_MOUSECD22_MOUSEBioGRID10373493 details
P85A_MOUSESHC1_MOUSEBioGRID10995764 details
P85A_MOUSEPTN11_MOUSEBioGRID10995764 32325033 details
P85A_MOUSERET_MOUSEBioGRID10995764 details
P85A_MOUSEARAF_MOUSEBioGRID10967104 details
P85A_MOUSEMAP6_MOUSEBioGRID26037503 details
P85A_MOUSEIRS1_HUMANIntAct12679424 details
P85A_MOUSEPGFRB_MOUSEIntAct15377662 details
P85A_MOUSEPTN6_HUMANIntAct12196526 details
P85A_MOUSERASH_MOUSEBioGRID, IntAct12196526 24470255 32325033 details
P85A_MOUSEIRS1_MOUSEBioGRID, MINT12783867 14684612 14966267 15169905 15183122 15249583 15380067 16455755 18059474 18296638 20804756 27708159 8557661 details
P85A_MOUSELYN_MOUSEMINT8395016 details
P85A_MOUSEBLK_MOUSEMINT8395016 details
P85A_MOUSEFYN_MOUSEBioGRID, MINT8395016 9115297 details
P85A_MOUSETIRAP_MOUSEMINT19574958 details
P85A_MOUSEABI1_HUMANMINT20598684 details
P85A_MOUSEEPOR_HUMANMINT7559499 details
P85A_MOUSETIE1_MOUSEMINT11865050 details
P85A_MOUSECD28_HUMANMINT8621607 details
P85A_MOUSEEP300_MOUSEBioGRID, I2D21057544 details
P85A_MOUSEWASF1_MOUSEBioGRID, MINT21946561 32325033 details
P85A_MOUSENYAP2_MOUSEMINT21946561 details
P85A_MOUSENYAP1_MOUSEBioGRID, MINT21946561 details
P85A_MOUSEMYO16_MOUSEBioGRID, MINT21946561 details
P85A_MOUSECBL_MOUSEBioGRID, IntAct10391678 10633073 10799548 10940298 11406619 15581361 15581362 16798838 17420256 20133944 27474268 32325033 8947469 9013636 9115297 9174058 9890970 details
P85A_MOUSETHB_MOUSEBioGRID, DIP16446424 17606624 details
P85A_MOUSESNX9_HUMANDIP17242350 details
P85A_MOUSEICOS_MOUSEIntAct27135603 details
P85A_MOUSEIRS2_MOUSEBioGRID15169905 15380067 details
P85A_MOUSECD19_MOUSEBioGRID11163197 details
P85A_MOUSEJAK2_MOUSEBioGRID22402124 8702385 details
P85A_MOUSENMDZ1_MOUSEBioGRID10862698 details
P85A_MOUSENMDE2_MOUSEBioGRID10862698 details
P85A_MOUSETNR11_MOUSEBioGRID11406619 details
P85A_MOUSETNR5_MOUSEBioGRID11406619 details
P85A_MOUSEGRB10_MOUSEBioGRID12783867 details
P85A_MOUSEERBB2_MOUSEBioGRID10940298 details
P85A_MOUSESH3K1_HUMANBioGRID21725061 details
P85A_MOUSEFOS_MOUSEBioGRID9115297 details
P85A_MOUSECADH1_MOUSEBioGRID15192701 details
P85A_MOUSECADH2_MOUSEBioGRID15192701 details
P85A_MOUSEEPOR_MOUSEBioGRID17420256 7505116 details
P85A_MOUSEDOK1_MOUSEBioGRID11031258 details
P85A_MOUSEPLAK_MOUSEBioGRID24567360 details
P85A_MOUSEAKT1_MOUSEBioGRID24567360 details
P85A_MOUSEPA2G4_MOUSEBioGRID24651434 details
P85A_MOUSEOSTP_MOUSEBioGRID25436971 details
P85A_MOUSEEPS8_MOUSEBioGRID12515821 details
P85A_MOUSEPGFRA_HUMANBioGRID21393858 details
P85A_MOUSEUFO_MOUSEBioGRID18346204 details
P85A_MOUSEBTLA_MOUSEBioGRID16725108 details
P85A_MOUSEINSR_MOUSEBioGRID7983060 details