Entity Details

Primary name PGFRA_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP26618
EntryNamePGFRA_MOUSE
FullNamePlatelet-derived growth factor receptor alpha
TaxID10090
Evidenceevidence at protein level
Length1089
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPdgfra

GO terms

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GOName
GO:0001553 luteinization
GO:0001701 in utero embryonic development
GO:0002244 hematopoietic progenitor cell differentiation
GO:0004672 protein kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005018 platelet-derived growth factor alpha-receptor activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0005929 cilium
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007275 multicellular organism development
GO:0008210 estrogen metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008585 female gonad development
GO:0009653 anatomical structure morphogenesis
GO:0009887 animal organ morphogenesis
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010544 negative regulation of platelet activation
GO:0010863 positive regulation of phospholipase C activity
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030054 cell junction
GO:0030198 extracellular matrix organization
GO:0030324 lung development
GO:0030325 adrenal gland development
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0030539 male genitalia development
GO:0031226 intrinsic component of plasma membrane
GO:0032991 protein-containing complex
GO:0033327 Leydig cell differentiation
GO:0033674 positive regulation of kinase activity
GO:0034614 cellular response to reactive oxygen species
GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway
GO:0038085 vascular endothelial growth factor binding
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0042060 wound healing
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042803 protein homodimerization activity
GO:0043235 receptor complex
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044877 protein-containing complex binding
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0048407 platelet-derived growth factor binding
GO:0048557 embryonic digestive tract morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050872 white fat cell differentiation
GO:0050920 regulation of chemotaxis
GO:0055003 cardiac myofibril assembly
GO:0060021 roof of mouth development
GO:0060325 face morphogenesis
GO:0060326 cell chemotaxis
GO:0060437 lung growth
GO:0061047 positive regulation of branching involved in lung morphogenesis
GO:0061298 retina vasculature development in camera-type eye
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071230 cellular response to amino acid stimulus
GO:0072277 metanephric glomerular capillary formation
GO:2000739 regulation of mesenchymal stem cell differentiation

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001824 Tyrosine-protein kinase, receptor class III, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027290 Platelet-derived growth factor receptor alphaFamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions