Entity Details

Primary name TLK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86UE8
EntryNameTLK2_HUMAN
FullNameSerine/threonine-protein kinase tousled-like 2
TaxID9606
Evidenceevidence at protein level
Length772
SequenceStatuscomplete
DateCreated2003-08-22
DateModified2021-06-02

Ontological Relatives

GenesTLK2

GO terms

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GOName
GO:0001672 regulation of chromatin assembly or disassembly
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005882 intermediate filament
GO:0006325 chromatin organization
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007059 chromosome segregation
GO:0010507 negative regulation of autophagy
GO:0018105 peptidyl-serine phosphorylation
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0071480 cellular response to gamma radiation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR027086 Serine/threonine-protein kinase TOUSLED-like 2FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

3 interactions