Entity Details

Primary name DTX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86Y01
EntryNameDTX1_HUMAN
FullNameE3 ubiquitin-protein ligase DTX1
TaxID9606
Evidenceevidence at protein level
Length620
SequenceStatuscomplete
DateCreated2003-09-26
DateModified2021-06-02

Ontological Relatives

GenesDTX1

GO terms

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GOName
GO:0003713 transcription coactivator activity
GO:0005112 Notch binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006351 transcription, DNA-templated
GO:0006366 transcription by RNA polymerase II
GO:0007166 cell surface receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0008270 zinc ion binding
GO:0008593 regulation of Notch signaling pathway
GO:0010001 glial cell differentiation
GO:0016567 protein ubiquitination
GO:0016604 nuclear body
GO:0017124 SH3 domain binding
GO:0031625 ubiquitin protein ligase binding
GO:0045581 negative regulation of T cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0061630 ubiquitin protein ligase activity
GO:1990830 cellular response to leukemia inhibitory factor

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR004170 WWE domainDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR018123 WWE domain, subgroupDomainDomain
IPR018957 Zinc finger, C3HC4 RING-typeDomainDomain
IPR037197 WWE domain superfamilyFamilyHomologous superfamily
IPR039396 Deltex, C-terminalDomainDomain
IPR039398 Deltex familyFamilyFamily
IPR039399 Deltex, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
DTX1_HUMANLAMP1_MOUSEMINT17028573 details
DTX1_HUMANEIF3F_MOUSEDIP21124883 details