Entity Details

Primary name RGRF1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP27671
EntryNameRGRF1_MOUSE
FullNameRas-specific guanine nucleotide-releasing factor 1
TaxID10090
Evidenceevidence at protein level
Length1262
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesRasgrf1

GO terms

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GOName
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007264 small GTPase mediated signal transduction
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0016323 basolateral plasma membrane
GO:0016327 apicolateral plasma membrane
GO:0019901 protein kinase binding
GO:0030426 growth cone
GO:0030971 receptor tyrosine kinase binding
GO:0031175 neuron projection development
GO:0031267 small GTPase binding
GO:0034976 response to endoplasmic reticulum stress
GO:0035020 regulation of Rac protein signal transduction
GO:0035023 regulation of Rho protein signal transduction
GO:0035254 glutamate receptor binding
GO:0043025 neuronal cell body
GO:0043547 positive regulation of GTPase activity
GO:0046578 regulation of Ras protein signal transduction
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048146 positive regulation of fibroblast proliferation
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0090630 activation of GTPase activity
GO:0097440 apical dendrite
GO:2000310 regulation of NMDA receptor activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000048 IQ motif, EF-hand binding siteSiteBinding site
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001849 Pleckstrin homology domainDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR019804 Ras guanine-nucleotide exchange factor, conserved siteSiteConserved site
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR030745 Ras-specific guanine nucleotide-releasing factor 1FamilyFamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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