Entity Details

Primary name LEF1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP27782
EntryNameLEF1_MOUSE
FullNameLymphoid enhancer-binding factor 1
TaxID10090
Evidenceevidence at protein level
Length397
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesLef1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001649 osteoblast differentiation
GO:0001756 somitogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0001944 vasculature development
GO:0002040 sprouting angiogenesis
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008301 DNA binding, bending
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0021542 dentate gyrus development
GO:0021766 hippocampus development
GO:0021861 forebrain radial glial cell differentiation
GO:0021873 forebrain neuroblast division
GO:0021943 formation of radial glial scaffolds
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0030111 regulation of Wnt signaling pathway
GO:0030223 neutrophil differentiation
GO:0030284 estrogen receptor activity
GO:0030326 embryonic limb morphogenesis
GO:0030331 estrogen receptor binding
GO:0030335 positive regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030854 positive regulation of granulocyte differentiation
GO:0030879 mammary gland development
GO:0032696 negative regulation of interleukin-13 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032993 protein-DNA complex
GO:0033153 T cell receptor V(D)J recombination
GO:0042100 B cell proliferation
GO:0042393 histone binding
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042826 histone deacetylase binding
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043565 sequence-specific DNA binding
GO:0043586 tongue development
GO:0043923 positive regulation by host of viral transcription
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045063 T-helper 1 cell differentiation
GO:0045295 gamma-catenin binding
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046632 alpha-beta T cell differentiation
GO:0048341 paraxial mesoderm formation
GO:0048468 cell development
GO:0050909 sensory perception of taste
GO:0060033 anatomical structure regression
GO:0060070 canonical Wnt signaling pathway
GO:0060325 face morphogenesis
GO:0060326 cell chemotaxis
GO:0060561 apoptotic process involved in morphogenesis
GO:0060710 chorio-allantoic fusion
GO:0061153 trachea gland development
GO:0062009 secondary palate development
GO:0070016 armadillo repeat domain binding
GO:0070742 C2H2 zinc finger domain binding
GO:0071345 cellular response to cytokine stimulus
GO:0071353 cellular response to interleukin-4
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0071866 negative regulation of apoptotic process in bone marrow cell
GO:0071895 odontoblast differentiation
GO:0071899 obsolete negative regulation of estrogen receptor binding
GO:0090068 positive regulation of cell cycle process
GO:1902262 apoptotic process involved in blood vessel morphogenesis
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990907 beta-catenin-TCF complex

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR013558 CTNNB1 binding, N-teminalDomainDomain
IPR024940 Transcription factor TCF/LEFFamilyFamily
IPR027397 Catenin binding domain superfamilyFamilyHomologous superfamily
IPR028769 Lymphoid enhancer-binding factor 1FamilyFamily
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

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