Entity Details

Primary name VAV_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP27870
EntryNameVAV_MOUSE
FullNameProto-oncogene vav
TaxID10090
Evidenceevidence at protein level
Length845
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesVav1

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0006909 phagocytosis
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008361 regulation of cell size
GO:0030217 T cell differentiation
GO:0030593 neutrophil chemotaxis
GO:0035556 intracellular signal transduction
GO:0042110 T cell activation
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0045785 positive regulation of cell adhesion
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046872 metal ion binding
GO:0072593 reactive oxygen species metabolic process
GO:0140031 phosphorylation-dependent protein binding

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001452 SH3 domainDomainDomain
IPR001715 Calponin homology domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR003096 Smooth muscle protein/calponinFamilyFamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domainDomainDomain
IPR028530 Protein vav1FamilyFamily
IPR035729 VAV1 protein, second SH3 domainDomainDomain
IPR035730 VAV1 protein, first SH3 domainDomainDomain
IPR035879 VAV1, SH2 domainDomainDomain
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily
IPR037832 Vav, PH domainDomainDomain

Diseases

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