Entity Details

Primary name HNF1B_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP27889
EntryNameHNF1B_MOUSE
FullNameHepatocyte nuclear factor 1-beta
TaxID10090
Evidenceevidence at protein level
Length558
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesHnf1b

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001706 endoderm formation
GO:0001714 endodermal cell fate specification
GO:0001822 kidney development
GO:0001826 inner cell mass cell differentiation
GO:0001889 liver development
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007219 Notch signaling pathway
GO:0007492 endoderm development
GO:0009749 response to glucose
GO:0009952 anterior/posterior pattern specification
GO:0010628 positive regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0030073 insulin secretion
GO:0030111 regulation of Wnt signaling pathway
GO:0030902 hindbrain development
GO:0031018 endocrine pancreas development
GO:0032922 circadian regulation of gene expression
GO:0035565 regulation of pronephros size
GO:0039020 pronephric nephron tubule development
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043565 sequence-specific DNA binding
GO:0044877 protein-containing complex binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048557 embryonic digestive tract morphogenesis
GO:0048598 embryonic morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048793 pronephros development
GO:0048806 genitalia development
GO:0050673 epithelial cell proliferation
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060429 epithelium development
GO:0060677 ureteric bud elongation
GO:0060993 kidney morphogenesis
GO:0061017 hepatoblast differentiation
GO:0061296 negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
GO:0065004 protein-DNA complex assembly
GO:0070365 hepatocyte differentiation
GO:0072095 regulation of branch elongation involved in ureteric bud branching
GO:0072164 mesonephric tubule development
GO:0072176 nephric duct development
GO:0072177 mesonephric duct development
GO:0072179 nephric duct formation
GO:0072181 mesonephric duct formation
GO:1900212 negative regulation of mesenchymal cell apoptotic process involved in metanephros development

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR006897 Hepatocyte nuclear factor 1, beta isoform, C-terminalDomainDomain
IPR006899 Hepatocyte nuclear factor 1, N-terminalDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR010982 Lambda repressor-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR023219 Hepatocyte nuclear factor 1, N-terminal domain superfamilyFamilyHomologous superfamily
IPR039066 Hepatocyte nuclear factor 1FamilyFamily

Diseases

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Interactions

4 interactions