Entity Details

Primary name BRAF_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP28028
EntryNameBRAF_MOUSE
FullNameSerine/threonine-protein kinase B-raf
TaxID10090
Evidenceevidence at protein level
Length751
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesBraf

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0002318 myeloid progenitor cell differentiation
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008542 visual learning
GO:0010628 positive regulation of gene expression
GO:0010764 negative regulation of fibroblast migration
GO:0010828 positive regulation of glucose transmembrane transport
GO:0016020 membrane
GO:0030154 cell differentiation
GO:0030878 thyroid gland development
GO:0031267 small GTPase binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035019 somatic stem cell population maintenance
GO:0035690 cellular response to drug
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043367 CD4-positive, alpha-beta T cell differentiation
GO:0043368 positive T cell selection
GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0043434 response to peptide hormone
GO:0043524 negative regulation of neuron apoptotic process
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045580 regulation of T cell differentiation
GO:0046632 alpha-beta T cell differentiation
GO:0048538 thymus development
GO:0048679 regulation of axon regeneration
GO:0048680 positive regulation of axon regeneration
GO:0050772 positive regulation of axonogenesis
GO:0050852 T cell receptor signaling pathway
GO:0051496 positive regulation of stress fiber assembly
GO:0051591 response to cAMP
GO:0060291 long-term synaptic potentiation
GO:0060323 head morphogenesis
GO:0060324 face development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070413 trehalose metabolism in response to stress
GO:0071277 cellular response to calcium ion
GO:0090150 establishment of protein localization to membrane
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000301 negative regulation of synaptic vesicle exocytosis
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR003116 Raf-like Ras-bindingDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily

Diseases

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