Entity Details

Primary name DUS1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP28563
EntryNameDUS1_MOUSE
FullNameDual specificity protein phosphatase 1
TaxID10090
Evidenceevidence at protein level
Length367
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesDusp1

GO terms

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GOName
GO:0000188 obsolete inactivation of MAPK activity
GO:0001706 endoderm formation
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006470 protein dephosphorylation
GO:0007162 negative regulation of cell adhesion
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0008285 negative regulation of cell population proliferation
GO:0008330 protein tyrosine/threonine phosphatase activity
GO:0009416 response to light stimulus
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0019838 growth factor binding
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0032870 cellular response to hormone stimulus
GO:0033574 response to testosterone
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035556 intracellular signal transduction
GO:0035970 peptidyl-threonine dephosphorylation
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0051019 mitogen-activated protein kinase binding
GO:0051384 response to glucocorticoid
GO:0051447 negative regulation of meiotic cell cycle
GO:0051591 response to cAMP
GO:0051592 response to calcium ion
GO:0070262 peptidyl-serine dephosphorylation
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0090027 negative regulation of monocyte chemotaxis
GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1903753 negative regulation of p38MAPK cascade
GO:1990869 cellular response to chemokine
GO:2000279 negative regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR001763 Rhodanese-like domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR008343 Mitogen-activated protein (MAP) kinase phosphataseFamilyFamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR020420 Atypical dual specificity phosphatase, subfamily BFamilyFamily
IPR020422 Dual specificity protein phosphatase domainDomainDomain
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036873 Rhodanese-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
DUS1_MOUSEPP2AB_MOUSEBioGRID20100830 details
DUS1_MOUSETERA_MOUSEBioGRID20100830 details