Entity Details

Primary name XRN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IZH2
EntryNameXRN1_HUMAN
FullName5'-3' exoribonuclease 1
TaxID9606
Evidenceevidence at protein level
Length1706
SequenceStatuscomplete
DateCreated2005-12-20
DateModified2021-06-02

Ontological Relatives

GenesXRN1

GO terms

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GOName
GO:0000932 P-body
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0002151 G-quadruplex RNA binding
GO:0003723 RNA binding
GO:0004534 5'-3' exoribonuclease activity
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016075 rRNA catabolic process
GO:0017148 negative regulation of translation
GO:0030425 dendrite
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0033574 response to testosterone
GO:0043025 neuronal cell body
GO:0043488 regulation of mRNA stability
GO:0045202 synapse
GO:0051880 G-quadruplex DNA binding
GO:0070034 telomerase RNA binding
GO:0071028 nuclear mRNA surveillance
GO:0071044 histone mRNA catabolic process
GO:0071409 cellular response to cycloheximide
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1905795 cellular response to puromycin

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR004859 Putative 5-3 exonucleaseDomainDomain
IPR016494 5'-3' exoribonuclease 1FamilyFamily
IPR027073 5'-3' exoribonucleaseFamilyFamily
IPR040992 Xrn1, D1 domainDomainDomain
IPR041106 Exoribonuclease Xrn1, D2/D3 domainDomainDomain
IPR041385 5'-3' exoribonuclease 1, SH3-like domainDomainDomain
IPR041412 Xrn1, helical domainDomainDomain

Diseases

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Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink