| Domain | Name | Category | Type |
| IPR001599 | Alpha-2-macroglobulin | Domain | Domain |
| IPR002890 | Macroglobulin domain | Domain | Domain |
| IPR008930 | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid | Family | Homologous superfamily |
| IPR009048 | Alpha-macroglobulin, receptor-binding | Domain | Domain |
| IPR010916 | TonB box, conserved site | Site | Conserved site |
| IPR011625 | Alpha-2-macroglobulin, bait region domain | Domain | Domain |
| IPR011626 | Alpha-macroglobulin-like, TED domain | Domain | Domain |
| IPR013783 | Immunoglobulin-like fold | Family | Homologous superfamily |
| IPR014756 | Immunoglobulin E-set | Family | Homologous superfamily |
| IPR019742 | Alpha-2-macroglobulin, conserved site | Site | Conserved site |
| IPR036595 | Alpha-macroglobulin, receptor-binding domain superfamily | Family | Homologous superfamily |
| IPR040839 | Macroglobulin domain MG4 | Domain | Domain |
| IPR041555 | Macroglobulin domain MG3 | Domain | Domain |
| IPR041813 | Alpha-2-macroglobulin, TED domain | Domain | Domain |