Entity Details

Primary name PIAS4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8N2W9
EntryNamePIAS4_HUMAN
FullNameE3 SUMO-protein ligase PIAS4
TaxID9606
Evidenceevidence at protein level
Length510
SequenceStatuscomplete
DateCreated2003-09-19
DateModified2021-06-02

Ontological Relatives

GenesPIAS4

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003677 DNA binding
GO:0003712 transcription coregulator activity
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008022 protein C-terminus binding
GO:0008270 zinc ion binding
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0016055 Wnt signaling pathway
GO:0016363 nuclear matrix
GO:0016605 PML body
GO:0016925 protein sumoylation
GO:0019789 SUMO transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033235 positive regulation of protein sumoylation
GO:0042359 vitamin D metabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0061665 SUMO ligase activity
GO:1902174 positive regulation of keratinocyte apoptotic process
GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1990234 transferase complex

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR003034 SAP domainDomainDomain
IPR004181 Zinc finger, MIZ-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR023321 PINIT domainDomainDomain
IPR027224 E3 SUMO-protein ligase PIAS4FamilyFamily
IPR036361 SAP domain superfamilyFamilyHomologous superfamily
IPR038654 PINIT domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PIAS4_HUMANP53_MOUSEIntAct11388671 15383276 details
PIAS4_HUMANGATA1_MOUSEBioGRID15173587 details