Entity Details

Primary name GRN_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP28798
EntryNameGRN_MOUSE
FullNameProgranulin
TaxID10090
Evidenceevidence at protein level
Length589
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesGrn

GO terms

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GOName
GO:0001835 blastocyst hatching
GO:0002265 astrocyte activation involved in immune response
GO:0002282 microglial cell activation involved in immune response
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0007040 lysosome organization
GO:0007041 lysosomal transport
GO:0007042 lysosomal lumen acidification
GO:0007566 embryo implantation
GO:0008284 positive regulation of cell population proliferation
GO:0010595 positive regulation of endothelial cell migration
GO:0010976 positive regulation of neuron projection development
GO:0016020 membrane
GO:0030335 positive regulation of cell migration
GO:0031982 vesicle
GO:0032355 response to estradiol
GO:0035641 locomotory exploration behavior
GO:0035988 chondrocyte proliferation
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0045824 negative regulation of innate immune response
GO:0048488 synaptic vesicle endocytosis
GO:0048680 positive regulation of axon regeneration
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050821 protein stabilization
GO:0051087 chaperone binding
GO:0051346 negative regulation of hydrolase activity
GO:0060041 retina development in camera-type eye
GO:0060179 male mating behavior
GO:0060266 negative regulation of respiratory burst involved in inflammatory response
GO:0060999 positive regulation of dendritic spine development
GO:0061351 neural precursor cell proliferation
GO:0098793 presynapse
GO:0106016 positive regulation of inflammatory response to wounding
GO:1900426 positive regulation of defense response to bacterium
GO:1902564 negative regulation of neutrophil activation
GO:1903334 positive regulation of protein folding
GO:1903979 negative regulation of microglial cell activation
GO:1905146 lysosomal protein catabolic process
GO:1905247 positive regulation of aspartic-type peptidase activity
GO:1905671 regulation of lysosome organization
GO:1905673 positive regulation of lysosome organization

Subcellular Location

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Subcellular Location
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR000118 GranulinDomainDomain
IPR037277 Granulin superfamilyFamilyHomologous superfamily
IPR039036 Granulin familyFamilyFamily

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
GRN_MOUSEAAPK1_HUMANBioGRID, IntAct20368287 details
GRN_MOUSESAP_MOUSEBioGRID, UniProt26370502 details
GRN_MOUSESLPI_MOUSEBioGRID12526812 details
GRN_MOUSETNR1B_MOUSEMINT24070898 details