Entity Details

Primary name PTN6_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP29351
EntryNamePTN6_MOUSE
FullNameTyrosine-protein phosphatase non-receptor type 6
TaxID10090
Evidenceevidence at protein level
Length595
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesPtpn6

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0006470 protein dephosphorylation
GO:0008284 positive regulation of cell population proliferation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0017124 SH3 domain binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0030154 cell differentiation
GO:0030220 platelet formation
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033277 abortive mitotic cell cycle
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035556 intracellular signal transduction
GO:0035855 megakaryocyte development
GO:0042105 alpha-beta T cell receptor complex
GO:0042130 negative regulation of T cell proliferation
GO:0042169 SH2 domain binding
GO:0042267 natural killer cell mediated cytotoxicity
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0045577 regulation of B cell differentiation
GO:0046703 natural killer cell lectin-like receptor binding
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050839 cell adhesion molecule binding
GO:0050853 B cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0140031 phosphorylation-dependent protein binding
GO:1905867 epididymis development
GO:2000045 regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11FamilyFamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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