Entity Details

Primary name CASP1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP29452
EntryNameCASP1_MOUSE
FullNameCaspase-1
TaxID10090
Evidenceevidence at protein level
Length402
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesCasp1

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001774 microglial cell activation
GO:0001819 positive regulation of cytokine production
GO:0004175 endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0007520 myoblast fusion
GO:0007613 memory
GO:0008233 peptidase activity
GO:0009617 response to bacterium
GO:0010506 regulation of autophagy
GO:0014070 response to organic cyclic compound
GO:0016485 protein processing
GO:0016540 protein autoprocessing
GO:0019900 kinase binding
GO:0032496 response to lipopolysaccharide
GO:0032730 positive regulation of interleukin-1 alpha production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032991 protein-containing complex
GO:0033198 response to ATP
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0050700 CARD domain binding
GO:0050727 regulation of inflammatory response
GO:0051882 mitochondrial depolarization
GO:0060081 membrane hyperpolarization
GO:0070269 pyroptosis
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071310 cellular response to organic substance
GO:0071346 cellular response to interferon-gamma
GO:0072557 IPAF inflammasome complex
GO:0072558 NLRP1 inflammasome complex
GO:0072559 NLRP3 inflammasome complex
GO:0097110 scaffold protein binding
GO:0097169 AIM2 inflammasome complex
GO:0097179 protease inhibitor complex
GO:0097194 execution phase of apoptosis
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097300 programmed necrotic cell death
GO:0140447 cytokine precursor processing
GO:0140448 signaling receptor ligand precursor processing
GO:1901998 toxin transport
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR001315 CARD domainDomainDomain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10DomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR016129 Peptidase family C14A, His active siteSiteActive site
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily
IPR033139 Peptidase family C14A, cysteine active siteSiteActive site

Diseases

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