Entity Details

Primary name NOS2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP29477
EntryNameNOS2_MOUSE
FullNameNitric oxide synthase, inducible
TaxID10090
Evidenceevidence at protein level
Length1144
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesNos2

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0003779 actin binding
GO:0004517 nitric-oxide synthase activity
GO:0005516 calmodulin binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006527 arginine catabolic process
GO:0006801 superoxide metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0006954 inflammatory response
GO:0007263 nitric oxide mediated signal transduction
GO:0007623 circadian rhythm
GO:0008013 beta-catenin binding
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0009617 response to bacterium
GO:0009725 response to hormone
GO:0010181 FMN binding
GO:0010629 negative regulation of gene expression
GO:0012506 vesicle membrane
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0018119 peptidyl-cysteine S-nitrosylation
GO:0019901 protein kinase binding
GO:0020037 heme binding
GO:0030863 cortical cytoskeleton
GO:0031284 positive regulation of guanylate cyclase activity
GO:0032310 prostaglandin secretion
GO:0032496 response to lipopolysaccharide
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0034617 tetrahydrobiopterin binding
GO:0034618 arginine binding
GO:0035690 cellular response to drug
GO:0042127 regulation of cell population proliferation
GO:0042177 negative regulation of protein catabolic process
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0045296 cadherin binding
GO:0045776 negative regulation of blood pressure
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0050796 regulation of insulin secretion
GO:0050998 nitric-oxide synthase binding
GO:0051712 positive regulation of killing of cells of other organism
GO:0051879 Hsp90 protein binding
GO:0071222 cellular response to lipopolysaccharide
GO:0071345 cellular response to cytokine stimulus
GO:0071346 cellular response to interferon-gamma
GO:0071407 cellular response to organic cyclic compound
GO:1900015 regulation of cytokine production involved in inflammatory response

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001094 Flavodoxin-likeDomainDomain
IPR001433 Oxidoreductase FAD/NAD(P)-bindingDomainDomain
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductaseDomainDomain
IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-bindingDomainDomain
IPR004030 Nitric oxide synthase, N-terminalDomainDomain
IPR008254 Flavodoxin/nitric oxide synthaseDomainDomain
IPR012144 Nitric-oxide synthase, eukaryoteFamilyFamily
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamilyFamilyHomologous superfamily
IPR029039 Flavoprotein-like superfamilyFamilyHomologous superfamily
IPR036119 Nitric oxide synthase, N-terminal domain superfamilyFamilyHomologous superfamily
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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